In situphase-changeable 2D MXene/zein bio-injection for shear wave elastography-guided tumor ablation in NIR-II bio-window
文献类型：期刊论文
| 作者 | Zhou, BG; Pu, YY; Lin, H; Yue, WW; Yin, HH; Yin, YF; Ren, WW; Zhao, CK; Chen, Y; Xu, HX |
| 刊名 | JOURNAL OF MATERIALS CHEMISTRY B
 |
| 出版日期 | 2020-06-28 |
| 期号 | 24页码:5257 |
| ISSN号 | 2050-750X |
| DOI | 10.1039/d0tb00519c |
| 文献子类 | Article |
| 英文摘要 | Localized tumor photothermal cancer ablation is a minimally invasive therapeutic modality for combating cancer, but it often suffers from low therapeutic efficacy and poor precision due to the poor accumulation and non-uniform distribution of used photothermal-conversion agents in tumor tissueviathe typical intravenous administration. To address this, an injectable and phase-changeable composite bio-injection consisting of biocompatible two-dimensional (2D) niobium carbide (Nb2C) MXene and the plant-originating protein, zein, has been engineered for near infrared (NIR)-II-triggered tumor photothermal ablation. Zein can respond to aqueous microenvironments and also external photo-triggers from the NIR-II bio-window (1064 nm), and transforms into a solid bio-implant after solvent exchange between ethanol and water. Which, thus, traps Nb2C MXene and heat, improving ablation efficiency and enabling the precise and complete eradication of 4T1 breast tumor cells without additional safety concerns. More significantly, shear wave elastography (SWE) as a deep-penetration imaging mode that can reflect the ablated outcomesviamonitoring tissue density variation, has been employed to guide the photo-thermal ablation process to further improve the ablation precision. Thus, this compatible and phase-changeable bio-injection capable of improving photo-thermal ablation efficiency holds great potential in clinical applications. |
| WOS关键词 | PERCUTANEOUS ETHANOL INJECTION ; PHOTOTHERMAL THERAPY ; HEPATOCELLULAR-CARCINOMA ; DRUG-DELIVERY ; ZEIN ; NANOSHEETS |
| WOS研究方向 | Materials Science |
| 语种 | 英语 |
| 出版者 | ROYAL SOC CHEMISTRY |
| 源URL | [http://ir.sic.ac.cn/handle/331005/27952]  |
| 专题 | 中国科学院上海硅酸盐研究所 |
| 推荐引用方式 GB/T 7714 | Zhou, BG,Pu, YY,Lin, H,et al. In situphase-changeable 2D MXene/zein bio-injection for shear wave elastography-guided tumor ablation in NIR-II bio-window[J]. JOURNAL OF MATERIALS CHEMISTRY B,2020(24):5257. |
| APA | Zhou, BG.,Pu, YY.,Lin, H.,Yue, WW.,Yin, HH.,...&Xu, HX.(2020).In situphase-changeable 2D MXene/zein bio-injection for shear wave elastography-guided tumor ablation in NIR-II bio-window.JOURNAL OF MATERIALS CHEMISTRY B(24),5257. |
| MLA | Zhou, BG,et al."In situphase-changeable 2D MXene/zein bio-injection for shear wave elastography-guided tumor ablation in NIR-II bio-window".JOURNAL OF MATERIALS CHEMISTRY B .24(2020):5257. |
入库方式： OAI收割
来源：上海硅酸盐研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。