Cellular architecture response to aspect ratio tunable nanoarrays
文献类型：期刊论文
| 作者 | Dai, J; Gong, JK; Kong, N; Yao, Y |
| 刊名 | NANOSCALE
 |
| 出版日期 | 2020-06-21 |
| 期号 | 23页码:12395 |
| ISSN号 | 2040-3364 |
| DOI | 10.1039/d0nr01003k |
| 文献子类 | Article |
| 英文摘要 | Nanoarrays have been emerging as popular nanostructure platforms to investigate both cell behaviors and biological functions, due to the cell architecture respondence to the biointerface of nanostructures. Herein, we developed a series of aspect ratio tunable nanoarrays through a metal-assisted chemical etching method. Nanoarrays including nanoneedles, nanopillars, and nanoclusters were fabricated with a controllable aspect ratio. We found that nanostructures with a high aspect ratio (>10) induced significant alterations of cell physiological behaviors such as surface attachment, architecture deformation, viability, proliferation and motility. The cells on nanostructures with a high aspect ratio exhibited reorganized actin stress fibers and vimentin filaments, as well as reduced focal adhesion. This research enlarges the diversity of nanostructures on nano-bio interface investigation, provides a new insight for the surface-dependent architecture of cells, and offers unbiased understanding of factors influencing cell physiology. |
| WOS关键词 | EPITHELIAL-MESENCHYMAL TRANSITION ; MEMBRANE CURVATURE ; SILICON NANOPILLARS ; ADHESION ; FABRICATION ; FORCE ; CELLS ; ARRAY ; MANIPULATION ; DIAMETER |
| WOS研究方向 | Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics |
| 语种 | 英语 |
| 出版者 | ROYAL SOC CHEMISTRY |
| 源URL | [http://ir.sic.ac.cn/handle/331005/27966]  |
| 专题 | 中国科学院上海硅酸盐研究所 |
| 推荐引用方式 GB/T 7714 | Dai, J,Gong, JK,Kong, N,et al. Cellular architecture response to aspect ratio tunable nanoarrays[J]. NANOSCALE,2020(23):12395. |
| APA | Dai, J,Gong, JK,Kong, N,&Yao, Y.(2020).Cellular architecture response to aspect ratio tunable nanoarrays.NANOSCALE(23),12395. |
| MLA | Dai, J,et al."Cellular architecture response to aspect ratio tunable nanoarrays".NANOSCALE .23(2020):12395. |
入库方式： OAI收割
来源：上海硅酸盐研究所
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