Tracking the interaction of drug molecules with individual mesoporous amorphous calcium phosphate/ATP nanocomposites - an X-ray spectromicroscopy study
文献类型：期刊论文
| 作者 | Jiang, YY; Wang, ZQ; Chen, JT; Li, J; Zhu, YJ; Liu, LJ; Guo, XX; Hu, YF; He, SS; Wu, J |
| 刊名 | PHYSICAL CHEMISTRY CHEMICAL PHYSICS
 |
| 出版日期 | 2020-06-21 |
| 期号 | 23页码:13108 |
| ISSN号 | 1463-9076 |
| DOI | 10.1039/d0cp00797h |
| 文献子类 | Article |
| 英文摘要 | Adenosine triphosphate (ATP) biomolecules play critial roles in the biomineralization process during the formation of amorphous calcium phosphate composites (ACPC), and ACPC is an important drug carrier due to its significant advantages of biocompatibility and biodegradability. Hence, studying the behavior of ACPC nanodrug carriers is crucial to investigate the structural regulation of biomimetic minerals and calcium phosphate (CaP)-based drug delivery systems. However, it is difficult to probe these interactions using traditional characterization methods. In this paper, XANES analysis together with STXM successfully provided a method to reveal the interaction of ATP and drug molecules with individual mesoporous ACPC. We found that the adenosine and phosphate groups of ATP biomolecules coordinated with Ca(2+)and played critical roles in the formation of ACPC; drug molecules with the -COOH groups were linked to Ca(2+)viacarboxylic acid groups primarily by electrostatic interactions, and the N-containing ring structures within the drug molecules also coordinated with Ca2+. |
| WOS关键词 | K-EDGE XANES ; SILICA NANOPARTICLES ; PHOSPHORUS SOURCE ; DISODIUM SALT ; BONE ; HYDROXYAPATITE ; ABSORPTION ; MICROSPHERES ; NUCLEATION ; DELIVERY |
| WOS研究方向 | Chemistry ; Physics |
| 语种 | 英语 |
| 出版者 | ROYAL SOC CHEMISTRY |
| 源URL | [http://ir.sic.ac.cn/handle/331005/27967]  |
| 专题 | 中国科学院上海硅酸盐研究所 |
| 推荐引用方式 GB/T 7714 | Jiang, YY,Wang, ZQ,Chen, JT,et al. Tracking the interaction of drug molecules with individual mesoporous amorphous calcium phosphate/ATP nanocomposites - an X-ray spectromicroscopy study[J]. PHYSICAL CHEMISTRY CHEMICAL PHYSICS,2020(23):13108. |
| APA | Jiang, YY.,Wang, ZQ.,Chen, JT.,Li, J.,Zhu, YJ.,...&Sham, TK.(2020).Tracking the interaction of drug molecules with individual mesoporous amorphous calcium phosphate/ATP nanocomposites - an X-ray spectromicroscopy study.PHYSICAL CHEMISTRY CHEMICAL PHYSICS(23),13108. |
| MLA | Jiang, YY,et al."Tracking the interaction of drug molecules with individual mesoporous amorphous calcium phosphate/ATP nanocomposites - an X-ray spectromicroscopy study".PHYSICAL CHEMISTRY CHEMICAL PHYSICS .23(2020):13108. |
入库方式： OAI收割
来源：上海硅酸盐研究所
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