Preparation and characterization of antibacterial dopamine-functionalized reduced graphene oxide/PLLA composite nanofibers
文献类型：期刊论文
| 作者 | Li, BY; Xiong, F; Yao, B; Du, Q; Cao, J; Qu, JG; Feng, W; Yuan, HH |
| 刊名 | RSC ADVANCES
 |
| 出版日期 | 2020-05-18 |
| 期号 | 32页码:18614 |
| DOI | 10.1039/d0ra03224g |
| 文献子类 | Article |
| 英文摘要 | Electrospun poly(l)-lactide (PLLA) ultrafine fibers are a biodegradable and biocompatible scaffold, widely used in tissue engineering applications. Unfortunately, these scaffolds have some limitations related to the absence of bioactivity and antibacterial capacity. In this study, dopamine-functionalized reduced graphene oxide (rGO)/PLLA composite nanofibers were fabricated via electrospinning. The morphology and the physicochemical and biological properties of the composite nanofibers were investigated. The results indicate that incorporating rGO improves the hydrophilic, mechanical, and biocompatibility properties of PLLA nanofibers. Tetracycline hydrochloride (TC)-loaded rGO/PLLA composite nanofibers showed better controlled drug release profiles compared to GO/PLLA and PLLA nanofibrous scaffolds. Drug-loaded nanofibrous scaffolds showed significantly improved antibacterial activity against Gram-negative Escherichia coli (E. coli) and Gram-positive Staphylococcus aureus (S. aureus). Additionally, rGO/PLLA composite nanofibers exhibited enhanced cytocompatibility. Thus, it can be concluded that rGO/PLLA composite nanofibers allow the development of multifunctional scaffolds for use in biomedical applications. |
| WOS关键词 | MESENCHYMAL STEM-CELLS ; DRUG-DELIVERY ; SILVER-NANOPARTICLE ; POLYMER NANOFIBERS ; ELECTROSPUN ; POLY(L-LACTIDE) ; BIOCOMPATIBILITY ; DIFFERENTIATION ; FIBERS |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| 出版者 | ROYAL SOC CHEMISTRY |
| 源URL | [http://ir.sic.ac.cn/handle/331005/28055]  |
| 专题 | 中国科学院上海硅酸盐研究所 |
| 推荐引用方式 GB/T 7714 | Li, BY,Xiong, F,Yao, B,et al. Preparation and characterization of antibacterial dopamine-functionalized reduced graphene oxide/PLLA composite nanofibers[J]. RSC ADVANCES,2020(32):18614. |
| APA | Li, BY.,Xiong, F.,Yao, B.,Du, Q.,Cao, J.,...&Yuan, HH.(2020).Preparation and characterization of antibacterial dopamine-functionalized reduced graphene oxide/PLLA composite nanofibers.RSC ADVANCES(32),18614. |
| MLA | Li, BY,et al."Preparation and characterization of antibacterial dopamine-functionalized reduced graphene oxide/PLLA composite nanofibers".RSC ADVANCES .32(2020):18614. |
入库方式： OAI收割
来源：上海硅酸盐研究所
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