Fe3O4 Mesocrystals with Distinctive Magnetothermal and Nanoenzyme Activity Enabling Self-Reinforcing Synergistic Cancer Therapy
文献类型：期刊论文
| 作者 | Du, WX; Liu, TZ; Xue, FF; Cai, XJ; Chen, A; Zheng, YY; Chen, HR |
| 刊名 | ACS APPLIED MATERIALS & INTERFACES
 |
| 出版日期 | 2020-04-29 |
| 期号 | 17页码:19285 |
| ISSN号 | 1944-8244 |
| DOI | 10.1021/acsami.0c02465 |
| 文献子类 | Article |
| 英文摘要 | Magnetite (Fe3O4) nanoparticles have been extensively used in noninvasive cancer treatment, for example, magnetic hyperthermia (MH) and chemodynamic therapy (CDT). However, how to achieve a highly efficient MH-CDT synergistic therapy based only on a single component of Fe3O4 still remains a challenge. Herein, hollow Fe3O4 mesocrystals (MCs) are constructed via a modified solvothermal method. Owing to the distinctive magnetic property of the mesocrystalline structure, Fe3O4 MCs show excellent magnetothermal conversion efficiency with a specific absorption rate of 722 w g(-1) at a Fe concentration of 0.6 mg mL(-)(1), much higher than that of Fe3O4 polycrystals (PCs). Moreover, Fe3O4 MCs also exhibit higher peroxidase-like activity than Fe3O4 PCs, which may be ascribed to the higher ratio of Fe2+/Fe3+ and more oxygen defects in the Fe3O4 MCs. Detailed in vivo results confirm that Fe3O4 MCs can instantly initiate CDT by producing the detrimental (OH)-O-center dot, and such boosted reactive oxygen levels not only induces cell apoptosis but also reduces the expression of heat shock proteins, thus enabling low-temperature-mediated MH. More importantly, the in situ rising temperature resulted from MH in turn facilitates CDT, thus achieving a self-augmented synergistic effect between MH and CDT. |
| WOS关键词 | XPS SPECTRA ; IN-VIVO ; NANOPARTICLES ; HYPERTHERMIA ; GENERATION ; NANORINGS |
| WOS研究方向 | Science & Technology - Other Topics ; Materials Science |
| 语种 | 英语 |
| 出版者 | AMER CHEMICAL SOC |
| 源URL | [http://ir.sic.ac.cn/handle/331005/28110]  |
| 专题 | 中国科学院上海硅酸盐研究所 |
| 推荐引用方式 GB/T 7714 | Du, WX,Liu, TZ,Xue, FF,et al. Fe3O4 Mesocrystals with Distinctive Magnetothermal and Nanoenzyme Activity Enabling Self-Reinforcing Synergistic Cancer Therapy[J]. ACS APPLIED MATERIALS & INTERFACES,2020(17):19285. |
| APA | Du, WX.,Liu, TZ.,Xue, FF.,Cai, XJ.,Chen, A.,...&Chen, HR.(2020).Fe3O4 Mesocrystals with Distinctive Magnetothermal and Nanoenzyme Activity Enabling Self-Reinforcing Synergistic Cancer Therapy.ACS APPLIED MATERIALS & INTERFACES(17),19285. |
| MLA | Du, WX,et al."Fe3O4 Mesocrystals with Distinctive Magnetothermal and Nanoenzyme Activity Enabling Self-Reinforcing Synergistic Cancer Therapy".ACS APPLIED MATERIALS & INTERFACES .17(2020):19285. |
入库方式： OAI收割
来源：上海硅酸盐研究所
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