Controlling Preosteoblast Behavior through Manganese Vacancy-Rich Birnessite with Enhanced Divalent Cation Modulation of Fibronectin-Integrin Interactions
文献类型：期刊论文
| 作者 | Liu, SW; Li, K; Hu, T; Wu, XD; Ao, HY; Xie, YT; Zheng, XB |
| 刊名 | ADVANCED MATERIALS INTERFACES
 |
| 出版日期 | 2020-06-01 |
| 期号 | 12 |
| ISSN号 | 2196-7350 |
| DOI | 10.1002/admi.201902127 |
| 文献子类 | Article |
| 英文摘要 | The osteoblast-function associated integrin-ligand interactions are known to be dependent on divalent cations, but there is scarce information about the effect of Ca2+ and Mg2+ adsorption properties of an implant surface on integrin alpha(5)beta(1)-fibronectin interactions and the subsequent osteoblast behavior. Cation adsorption properties are closely associated with the extent of structural defects in materials. Here, the birnessite-type MnO2 coatings with different amounts of manganese vacancy (V-Mn) are prepared on Ti substrates via hydrothermal treatment (denoted as 1M100-Ti, 5M100-Ti, and 5M120-Ti). The 5M120-Ti surface with hierarchical flower-like structure and the most stacked [MnO6] layers possess the highest V-Mn content, which is determined by the ratios of Mn3+/Mn4+ and K/Mn. The increased V-Mn content enhances the Ca2+ and Mg2+ adsorption properties of the birnessite coatings. When immersed in Ca2+/Mg2+ aqueous solution, the birnessite coatings significantly promote fibronectin adsorption and the exposure of cell-binding domains on adsorbed fibronectin with 5M120-Ti showing the greatest enhancement. Accordingly, the 5M120-Ti surface provides more alpha(5)beta(1)-integrin-specific instructions to MC3T3-E1 preosteoblasts capable of enhancing spreading and osteoblastic differentiation compared to two other samples. This study may provide a prospective approach of modulation of integrin-ligand interactions for controlling cell behavior by adjusting metal vacancies in metal oxides coatings. |
| WOS关键词 | AVERAGE OXIDATION-STATES ; CELL-ADHESION ; METAL-IONS ; SURFACE ; CALCIUM ; ADSORPTION ; TITANIUM ; PROTEIN ; MICROSTRUCTURE ; OXIDES |
| WOS研究方向 | Chemistry ; Materials Science |
| 语种 | 英语 |
| 出版者 | WILEY |
| 源URL | [http://ir.sic.ac.cn/handle/331005/28111]  |
| 专题 | 中国科学院上海硅酸盐研究所 |
| 推荐引用方式 GB/T 7714 | Liu, SW,Li, K,Hu, T,et al. Controlling Preosteoblast Behavior through Manganese Vacancy-Rich Birnessite with Enhanced Divalent Cation Modulation of Fibronectin-Integrin Interactions[J]. ADVANCED MATERIALS INTERFACES,2020(12). |
| APA | Liu, SW.,Li, K.,Hu, T.,Wu, XD.,Ao, HY.,...&Zheng, XB.(2020).Controlling Preosteoblast Behavior through Manganese Vacancy-Rich Birnessite with Enhanced Divalent Cation Modulation of Fibronectin-Integrin Interactions.ADVANCED MATERIALS INTERFACES(12). |
| MLA | Liu, SW,et al."Controlling Preosteoblast Behavior through Manganese Vacancy-Rich Birnessite with Enhanced Divalent Cation Modulation of Fibronectin-Integrin Interactions".ADVANCED MATERIALS INTERFACES .12(2020). |
入库方式： OAI收割
来源：上海硅酸盐研究所
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