Cocrystal Strategy toward Multifunctional 3D-Printing Scaffolds Enables NIR-Activated Photonic Osteosarcoma Hyperthermia and Enhanced Bone Defect Regeneration
文献类型：期刊论文
| 作者 | Xiang, HJ; Yang, QH; Gao, YS; Zhu, DY; Pan, SS; Xu, TM; Chen, Y |
| 刊名 | ADVANCED FUNCTIONAL MATERIALS
 |
| 出版日期 | 2020-06-18 |
| 期号 | 25 |
| ISSN号 | 1616-301X |
| DOI | 10.1002/adfm.201909938 |
| 文献子类 | Article |
| 英文摘要 | Malignant bone tumors are one of the major serious diseases in clinic. Inferior reconstruction of new bone and rapid propagation of residual tumor cells are the main challenges to surgical intervention. Herein, a bifunctional DTC@BG scaffold for near-infrared (NIR)-activated photonic thermal ablation of osteosarcoma and accelerated bone defect regeneration is engineered by in situ growth of NIR-absorbing cocrystal (DTC) on the surface of a 3D-printing bioactive glass (BG) scaffold. The prominent photothermal conversion performance and outstanding bone regeneration capability of DTC@BG scaffolds originate from the precise tailoring of the bandgap between the electron donors and acceptors of DTC and promote new bone growth performance of BG scaffolds. DTC@BG scaffolds not only significantly promote tumor cell ablation in vitro, but also effectively facilitate bone tumor suppression in vivo. In particular, DTC@BG scaffolds exhibit excellent capability in stimulating osteogenic differentiation and angiogenesis, and finally promote newborn bone formation in the bone defects. This research represents the first paradigm for ablating osteosarcoma and facilitating new bone formation through precise modulation of electron donors and acceptors in the cocrystal, which offers a new avenue to construct high-efficiency therapeutic platforms based on cocrystal strategy for ablation of malignant bone tumor. |
| WOS关键词 | THERAPY ; NANOCRYSTALS ; ABSORPTION ; SURVIVAL |
| WOS研究方向 | Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics |
| 语种 | 英语 |
| 出版者 | WILEY-V C H VERLAG GMBH |
| 源URL | [http://ir.sic.ac.cn/handle/331005/28112]  |
| 专题 | 中国科学院上海硅酸盐研究所 |
| 推荐引用方式 GB/T 7714 | Xiang, HJ,Yang, QH,Gao, YS,et al. Cocrystal Strategy toward Multifunctional 3D-Printing Scaffolds Enables NIR-Activated Photonic Osteosarcoma Hyperthermia and Enhanced Bone Defect Regeneration[J]. ADVANCED FUNCTIONAL MATERIALS,2020(25). |
| APA | Xiang, HJ.,Yang, QH.,Gao, YS.,Zhu, DY.,Pan, SS.,...&Chen, Y.(2020).Cocrystal Strategy toward Multifunctional 3D-Printing Scaffolds Enables NIR-Activated Photonic Osteosarcoma Hyperthermia and Enhanced Bone Defect Regeneration.ADVANCED FUNCTIONAL MATERIALS(25). |
| MLA | Xiang, HJ,et al."Cocrystal Strategy toward Multifunctional 3D-Printing Scaffolds Enables NIR-Activated Photonic Osteosarcoma Hyperthermia and Enhanced Bone Defect Regeneration".ADVANCED FUNCTIONAL MATERIALS .25(2020). |
入库方式： OAI收割
来源：上海硅酸盐研究所
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