Accurate and Real-Time Temperature Monitoring during MR Imaging Guided PTT
文献类型：期刊论文
| 作者 | Meng, XF; Zhang, BY; Yi, Y; Cheng, H; Wang, BM; Liu, YY; Gong, T; Yang, W; Yao, YF; Wang, H |
| 刊名 | NANO LETTERS
 |
| 出版日期 | 2020-04-08 |
| 期号 | 4页码:2522 |
| ISSN号 | 1530-6984 |
| DOI | 10.1021/acs.nanolett.9b05267 |
| 文献子类 | Article |
| 英文摘要 | Photothermal therapy (PTT) is an efficient approach for cancer treatment. However, accurately monitoring the spatial distribution of photothermal transducing agents (PTAs) and mapping the real-time temperature change in tumor and peritumoral normal tissue remain a huge challenge. Here, we propose an innovative strategy to integrate T-1-MRI for precisely tracking PTAs with magnetic resonance temperature imaging (MRTI) for real-time monitoring temperature change in vivo during PTT. NaBiF4: Gd@PDA@PEG nanomaterials were synthesized with favorable T-1-weighted performance to target tumor and localize PTAs. The extremely weak susceptibility (1.04 X 10(-6) emu g(-1)Oe(1-)) of NaBiF4: Gd@PDA@PEG interferes with the local phase marginally, which maintains the capability of MRTI to dynamically record real-time temperature change in tumor and peritumoral normal tissue. The time resolution is 19 s per frame, and the detection precision of temperature change is approximately 0.1 K. The approach achieving PTT guided by multimode MRI holds significant potential for the clinical application. |
| WOS关键词 | PHOTOTHERMAL THERAPY ; CANCER ; THERMOMETRY ; NANOPARTICLES ; NANOMATERIALS ; HYPERTHERMIA ; GRAPHENE ; TISSUE ; OXIDE |
| WOS研究方向 | Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics |
| 语种 | 英语 |
| 出版者 | AMER CHEMICAL SOC |
| 源URL | [http://ir.sic.ac.cn/handle/331005/28150]  |
| 专题 | 中国科学院上海硅酸盐研究所 |
| 推荐引用方式 GB/T 7714 | Meng, XF,Zhang, BY,Yi, Y,et al. Accurate and Real-Time Temperature Monitoring during MR Imaging Guided PTT[J]. NANO LETTERS,2020(4):2522. |
| APA | Meng, XF.,Zhang, BY.,Yi, Y.,Cheng, H.,Wang, BM.,...&Bu, WB.(2020).Accurate and Real-Time Temperature Monitoring during MR Imaging Guided PTT.NANO LETTERS(4),2522. |
| MLA | Meng, XF,et al."Accurate and Real-Time Temperature Monitoring during MR Imaging Guided PTT".NANO LETTERS .4(2020):2522. |
入库方式： OAI收割
来源：上海硅酸盐研究所
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