Auger Electrons Constructed Active Sites on Nanocatalysts for Catalytic Internal Radiotherapy
文献类型：期刊论文
| 作者 | Su, WW; Wang, H; Wang, T; Li, X; Tang, ZM; Zhao, S; Zhang, M; Li, DN; Jiang, XW; Gong, T |
| 刊名 | ADVANCED SCIENCE
 |
| 出版日期 | 2020-05-01 |
| 期号 | 10 |
| DOI | 10.1002/advs.201903585 |
| 文献子类 | Article |
| 英文摘要 | Excess electrons play important roles for the construction of superficial active sites on nanocatalysts. However, providing excess electrons to nanocatalysts in vivo is still a challenge, which limits the applications of nanocatalysts in biomedicine. Herein, auger electrons (AEs) emitted from radionuclide 125 (I-125) are used in situ to construct active sites in a nanocatalyst (TiO2) and the application of this method is further extended to cancer catalytic internal radiotherapy (CIRT). The obtained I-125-TiO2 nanoparticles first construct superficial Ti3+ active sites via the reaction between Ti4+ and AEs. Then Ti3+ stretches and weakens the O-H bond of the absorbed H2O, thus enhancing the radiolysis of H2O molecules and generating hydroxyl radicals (center dot OH). All in vitro and in vivo results demonstrate a good CIRT performance. These findings will broaden the application of radionuclides and introduce new perspectives to nanomedicine. |
| WOS关键词 | IONIZING-RADIATION ; SEED IMPLANTATION ; BRACHYTHERAPY ; NANOPARTICLES ; SCINTILLATOR ; INDUCTION ; CRYSTALS ; SURFACES ; THERAPY ; DNA |
| WOS研究方向 | Chemistry ; Science & Technology - Other Topics ; Materials Science |
| 语种 | 英语 |
| 出版者 | WILEY |
| 源URL | [http://ir.sic.ac.cn/handle/331005/28151]  |
| 专题 | 中国科学院上海硅酸盐研究所 |
| 推荐引用方式 GB/T 7714 | Su, WW,Wang, H,Wang, T,et al. Auger Electrons Constructed Active Sites on Nanocatalysts for Catalytic Internal Radiotherapy[J]. ADVANCED SCIENCE,2020(10). |
| APA | Su, WW.,Wang, H.,Wang, T.,Li, X.,Tang, ZM.,...&Bu, WB.(2020).Auger Electrons Constructed Active Sites on Nanocatalysts for Catalytic Internal Radiotherapy.ADVANCED SCIENCE(10). |
| MLA | Su, WW,et al."Auger Electrons Constructed Active Sites on Nanocatalysts for Catalytic Internal Radiotherapy".ADVANCED SCIENCE .10(2020). |
入库方式： OAI收割
来源：上海硅酸盐研究所
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