Full-Process Radiosensitization Based on Nanoscale Metal-Organic Frameworks
文献类型：期刊论文
| 作者 | Gong, T; Li, YL; Lv, B; Wang, H; Liu, YY; Yang, W; Wu, YL; Jiang, XW; Gao, HB; Zheng, XP |
| 刊名 | ACS NANO
 |
| 出版日期 | 2020-03-24 |
| 期号 | 3页码:3032 |
| ISSN号 | 1936-0851 |
| DOI | 10.1021/acsnano.9b07898 |
| 文献子类 | Article |
| 英文摘要 | Full-process radiosensitization, that is, pre-increasing radiation sensitivity of cancer cells, magnifying center dot OH formation during ionizing irradiation, and intervention on the resultant DNA repair for final cells death, could enhance the overall radiotherapeutic effects, but has not yet been achieved. Herein, Hf-nMOFs with Fe3+ ions uniformly dispersed (Hf-BPY-Fe) were constructed to integratedly improve radiotherapeutic effects via a multifaceted mechanism. The in vitro experiments demonstrated that persistent reactive oxygen species stress from Hf-BPY-Fe-activated in situ Fenton reaction reassorted cell cycle distribution, consequently contributing to increased tumoral radiosensitivity to photon radiation. Upon irradiation during the course of radiation therapy, Hf4+ in Hf-BPY-Fe gave substantial amounts of high-energy electrons, which partially converted H2O to center dot OH and, meanwhile, relaxed to a low-energy state in nMOF pores, leading to an electron-rich environment. These aggregated electrons facilitated the reduction from Fe3+ to Fe2+ and further promoted the production of center dot OH in the Fenton process to attack DNA. The Hf-BPY-Fe postponed the DNA damage response process by interfering with certain proteins involved in the DNA repair signaling pathway. The in vivo experiments showed improved radiotherapeutic effects from integrated contributions from Fe3+-based Fenton reaction and Hf4+-induced X-ray energy conversion in tumors. This work provides a nMOFs-based full-process radiosensitizing approach for better radiotherapeutic efficacy. |
| WOS关键词 | RADIATION-THERAPY ; IN-VIVO ; SUSCEPTIBILITY ; WATER ; PH |
| WOS研究方向 | Chemistry ; Science & Technology - Other Topics ; Materials Science |
| 语种 | 英语 |
| 出版者 | AMER CHEMICAL SOC |
| 源URL | [http://ir.sic.ac.cn/handle/331005/28212]  |
| 专题 | 中国科学院上海硅酸盐研究所 |
| 推荐引用方式 GB/T 7714 | Gong, T,Li, YL,Lv, B,et al. Full-Process Radiosensitization Based on Nanoscale Metal-Organic Frameworks[J]. ACS NANO,2020(3):3032. |
| APA | Gong, T.,Li, YL.,Lv, B.,Wang, H.,Liu, YY.,...&Bu, WB.(2020).Full-Process Radiosensitization Based on Nanoscale Metal-Organic Frameworks.ACS NANO(3),3032. |
| MLA | Gong, T,et al."Full-Process Radiosensitization Based on Nanoscale Metal-Organic Frameworks".ACS NANO .3(2020):3032. |
入库方式： OAI收割
来源：上海硅酸盐研究所
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