Design of a Multifunctional Biomaterial Inspired by Ancient Chinese Medicine for Hair Regeneration in Burned Skin
文献类型：期刊论文
| 作者 | Zhang, ZWB; Dai, QX; Zhang, Y; Zhuang, H; Wang, ED; Xu, Q; Ma, LL; Wu, CT; Huan, ZG; Guo, F |
| 刊名 | ACS APPLIED MATERIALS & INTERFACES
 |
| 出版日期 | 2020-03-18 |
| 期号 | 11页码:12489 |
| ISSN号 | 1944-8244 |
| DOI | 10.1021/acsami.9b22769 |
| 文献子类 | Article |
| 英文摘要 | In deep burn injuries, the dermis of the skin is often severely damaged, and hair follicles are also lost and lose the potential for regeneration. Therefore, the development of wound dressings that promote hair follicle regeneration has important clinical significance. In this study, inspired by an ancient Chinese medicine prescription, a novel fibrous membrane (P/Qu/Cup; P, PCL; Qu, quercetin; Cup, cuprorivaite, CaCuSi4O10) containing quercetin-copper (Qu-Cu) chelates was fabricated by using quercetin and a highly bioactive bioceramic (CaCuSi4O10) incorporated in PCL/gelatin electrospun fibers. The fibrous membrane can effectively release Qu and Cu ions to induce proliferation, migration, and differentiation of skin and hair follicle related cells, and the Qu, Cu ions, and Si ions released from the composite membrane revealed synergistic activity to stimulate hair follicle regeneration and wound healing. Our study demonstrated that the analysis of the common components in ancient Chinese prescription is an effective approach to design novel bioactive materials for regenerative medicine. |
| WOS关键词 | IN-VITRO ; QUERCETIN ; FOLLICLE ; ANTIOXIDANT ; NANOPARTICLES ; COMPLEXES ; HYDROGELS ; GROWTH ; COPPER ; CELLS |
| WOS研究方向 | Science & Technology - Other Topics ; Materials Science |
| 语种 | 英语 |
| 出版者 | AMER CHEMICAL SOC |
| 源URL | [http://ir.sic.ac.cn/handle/331005/28221]  |
| 专题 | 中国科学院上海硅酸盐研究所 |
| 推荐引用方式 GB/T 7714 | Zhang, ZWB,Dai, QX,Zhang, Y,et al. Design of a Multifunctional Biomaterial Inspired by Ancient Chinese Medicine for Hair Regeneration in Burned Skin[J]. ACS APPLIED MATERIALS & INTERFACES,2020(11):12489. |
| APA | Zhang, ZWB.,Dai, QX.,Zhang, Y.,Zhuang, H.,Wang, ED.,...&Chang, J.(2020).Design of a Multifunctional Biomaterial Inspired by Ancient Chinese Medicine for Hair Regeneration in Burned Skin.ACS APPLIED MATERIALS & INTERFACES(11),12489. |
| MLA | Zhang, ZWB,et al."Design of a Multifunctional Biomaterial Inspired by Ancient Chinese Medicine for Hair Regeneration in Burned Skin".ACS APPLIED MATERIALS & INTERFACES .11(2020):12489. |
入库方式： OAI收割
来源：上海硅酸盐研究所
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