Design strategy of optical probes for tumor hypoxia imaging
文献类型：期刊论文
| 作者 | Xue, FF; Chen, JF; Chen, HR |
| 刊名 | SCIENCE CHINA-LIFE SCIENCES
 |
| 出版日期 | 2020-03-07 |
| ISSN号 | 1674-7305 |
| DOI | 10.1007/s11427-019-1569-4 |
| 文献子类 | Review; Early Access |
| 英文摘要 | Clinical manifestations of tumors indicate that malignant phenotypes developing in the hypoxic microenvironment lead to resistance to cancer treatment, rendering chemotherapy, radiotherapy, and photodynamic therapy less sensitive and effective in patients with tumor. Visualizing the oxygen level in the tumor environment has garnered much attention due to its implications in precision tumor therapy. Following the rapid development of biomaterials in nanotechnology, various nanomaterials have been designed to visualize the oxygen levels in tumors. Here, we review recent research on detecting oxygen levels in solid tumors for tumor hypoxia imaging. To monitor the hypoxic level of tumors, two main strategies were investigated: directly detecting oxygen levels in tumors and monitoring the hypoxia-assisted reduced microenvironment. We believe that hypoxia as a tumor-specific microenvironment can be a breakthrough in the clinical treatment of tumors. |
| WOS关键词 | INDUCIBLE FACTOR-I ; EXTRACELLULAR-MATRIX ; NANOPARTICLE THERAPEUTICS ; FLUORESCENT-PROBES ; GENE-EXPRESSION ; DENDRITIC CELLS ; DRUG-DELIVERY ; STROMAL CELLS ; SOLID TUMORS ; CANCER |
| WOS研究方向 | Life Sciences & Biomedicine - Other Topics |
| 语种 | 英语 |
| 出版者 | SCIENCE PRESS |
| 源URL | [http://ir.sic.ac.cn/handle/331005/28237]  |
| 专题 | 中国科学院上海硅酸盐研究所 |
| 推荐引用方式 GB/T 7714 | Xue, FF,Chen, JF,Chen, HR. Design strategy of optical probes for tumor hypoxia imaging[J]. SCIENCE CHINA-LIFE SCIENCES,2020. |
| APA | Xue, FF,Chen, JF,&Chen, HR.(2020).Design strategy of optical probes for tumor hypoxia imaging.SCIENCE CHINA-LIFE SCIENCES. |
| MLA | Xue, FF,et al."Design strategy of optical probes for tumor hypoxia imaging".SCIENCE CHINA-LIFE SCIENCES (2020). |
入库方式： OAI收割
来源：上海硅酸盐研究所
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