Biointerface mediates cytoskeletal rearrangement of pancreatic cancer cell and modulates its drug sensitivity
文献类型：期刊论文
| 作者 | Dai, J; Wang, YQ; Wu, DH; Wan, FJ; Lu, Y; Kong, N; Li, XC; Gong, JK; Ling, SJ; Yao, Y |
| 刊名 | COLLOID AND INTERFACE SCIENCE COMMUNICATIONS
 |
| 出版日期 | 2020-03-01 |
| ISSN号 | 2215-0382 |
| DOI | 10.1016/j.colcom.2020.100250 |
| 文献子类 | Article |
| 英文摘要 | Cells sense extracellular matrix to direct behaviors. Tumors take collagen fibers reorganized from curl or random fibers to straightened and aligned fibers during tumorigenesis. Here, we fabricated three nanofiber sheets with different orientation to investigate topographic effect on drug sensitivity of pancreatic cancer cell (PANC-1). These three nanofiber sheets were patterned as random, orthogonal and aligned matrix. We found cell responded to topography by morphological change. In aligned nanofiber, the area and perimeter of cells were enhanced. These changes in morphology were associated with the varying sensitivity to anti-cancer drugs as gemcitabine and paclitaxel. We found filaments of actin and vimentin were reorganized by topographic cues, and keratin protein were expressed in a higher level when cells on aligned nanofiber. These initial results highlight the impact of surface topographic effect on drug sensitivity to pancreatic cancer cells. |
| WOS关键词 | VIMENTIN INTERMEDIATE-FILAMENTS ; EPITHELIAL-MESENCHYMAL TRANSITION ; ELECTROSPUN ; SCAFFOLDS ; NANOFIBER ; COEXPRESSION ; FABRICATION ; MIGRATION ; ADHESION ; COLLAGEN |
| WOS研究方向 | Chemistry ; Science & Technology - Other Topics ; Materials Science |
| 语种 | 英语 |
| 出版者 | ELSEVIER |
| 源URL | [http://ir.sic.ac.cn/handle/331005/28246]  |
| 专题 | 中国科学院上海硅酸盐研究所 |
| 推荐引用方式 GB/T 7714 | Dai, J,Wang, YQ,Wu, DH,et al. Biointerface mediates cytoskeletal rearrangement of pancreatic cancer cell and modulates its drug sensitivity[J]. COLLOID AND INTERFACE SCIENCE COMMUNICATIONS,2020. |
| APA | Dai, J.,Wang, YQ.,Wu, DH.,Wan, FJ.,Lu, Y.,...&Yao, Y.(2020).Biointerface mediates cytoskeletal rearrangement of pancreatic cancer cell and modulates its drug sensitivity.COLLOID AND INTERFACE SCIENCE COMMUNICATIONS. |
| MLA | Dai, J,et al."Biointerface mediates cytoskeletal rearrangement of pancreatic cancer cell and modulates its drug sensitivity".COLLOID AND INTERFACE SCIENCE COMMUNICATIONS (2020). |
入库方式： OAI收割
来源：上海硅酸盐研究所
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