3D printing of Haversian bone-mimicking scaffolds for multicellular delivery in bone regeneration
文献类型：期刊论文
| 作者 | Zhang, M; Lin, RC; Wang, X; Xue, JM; Deng, CJ; Feng, C; Zhuang, H; Ma, JG; Qin, C; Wan, L |
| 刊名 | SCIENCE ADVANCES
 |
| 出版日期 | 2020-03-01 |
| 期号 | 12 |
| ISSN号 | 2375-2548 |
| DOI | 10.1126/sciadv.aaz6725 |
| 文献子类 | Article |
| 英文摘要 | The integration of structure and function for tissue engineering scaffolds is of great importance in mimicking native bone tissue. However, the complexity of hierarchical structures, the requirement for mechanical properties, and the diversity of bone resident cells are the major challenges in constructing biomimetic bone tissue engineering scaffolds. Herein, a Haversian bone- mimicking scaffold with integrated hierarchical Haversian bone structure was successfully prepared via digital laser processing (DLP)-based 3D printing. The compressive strength and porosity of scaffolds could be well controlled by altering the parameters of the Haversian bone-mimicking structure. The Haversian bone-mimicking scaffolds showed great potential for multicellular delivery by inducing osteogenic, angiogenic, and neurogenic differentiation in vitro and accelerated the ingrowth of blood vessels and new bone formation in vivo. The work offers a new strategy for designing structured and functionalized biomaterials through mimicking native complex bone tissue for tissue regeneration. |
| WOS关键词 | MESENCHYMAL STEM-CELLS ; ENDOTHELIAL-CELLS ; DIFFERENTIATION ; HYDROGEL ; GELATIN |
| WOS研究方向 | Science & Technology - Other Topics |
| 语种 | 英语 |
| 出版者 | AMER ASSOC ADVANCEMENT SCIENCE |
| 源URL | [http://ir.sic.ac.cn/handle/331005/28257]  |
| 专题 | 中国科学院上海硅酸盐研究所 |
| 推荐引用方式 GB/T 7714 | Zhang, M,Lin, RC,Wang, X,et al. 3D printing of Haversian bone-mimicking scaffolds for multicellular delivery in bone regeneration[J]. SCIENCE ADVANCES,2020(12). |
| APA | Zhang, M.,Lin, RC.,Wang, X.,Xue, JM.,Deng, CJ.,...&Wu, CT.(2020).3D printing of Haversian bone-mimicking scaffolds for multicellular delivery in bone regeneration.SCIENCE ADVANCES(12). |
| MLA | Zhang, M,et al."3D printing of Haversian bone-mimicking scaffolds for multicellular delivery in bone regeneration".SCIENCE ADVANCES .12(2020). |
入库方式： OAI收割
来源：上海硅酸盐研究所
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