Cathodic protected Mn2+ by NaxWO3 nanorods for stable magnetic resonance imaging-guided tumor photothermal therapy
文献类型：期刊论文
| 作者 | Liu, Y; Wu, SM; Liu, YY; Zhang, H; Zhang, M; Tang, ZM; Wang, Y; Gong, T; Yao, ZW; Fang, XM |
| 刊名 | BIOMATERIALS
 |
| 出版日期 | 2020-03-01 |
| ISSN号 | 0142-9612 |
| DOI | 10.1016/j.biomaterials.2020.119762 |
| 文献子类 | Article |
| 英文摘要 | The stability and safety of magnetic resonance imaging (MRI) contrast agents (CAs) are crucial for accurate diagnosis and real-time monitor of tumor development. Paramagnetic Mn2+ as nonlanthanide metal ion has been widely studied for use in T-1-MRI CAs, but unfortunately, Mn2+ can be oxidized by H2O2 in tumor to nonparamagnetic Mn4+ via a Fenton-like reaction. The concurrent loss of paramagnetism and production of toxic hydroxyl radical (center dot OH) go against the basic requirment of CAs, thus restricting the further development of Mn2+-based CM. Based on the different standard potential of W6+/W5+ (similar to 0.26 V) and Mn4+/Mn2+ (similar to 1.2 V), a "cathodic protection" strategy was exploited in Mn2+-doped NaxWO3 nanorods (NaxMnWO3), with W5+ as the sacrificial anode and Mn2+ as the protected cathode, to protect Mn2+ from oxidation in tumor for stable MR contrast performance, as well as repress its Fenton-like reaction activity for good biosafety. Moreover, the tungsten bronze crystal structure endows NaxMnWO3 with excellent near-infrared (NIR)-photothennal properties for effective tumor hyperthermia, without effect from the changed oxidation state of W. This "cathodic protection" strategy offers a new method for the development of reliable and hypotoxic biomaterials for stable imaging and therapeutic applications in clinic. |
| WOS关键词 | BRAIN |
| WOS研究方向 | Engineering ; Materials Science |
| 语种 | 英语 |
| 出版者 | ELSEVIER SCI LTD |
| 源URL | [http://ir.sic.ac.cn/handle/331005/28266]  |
| 专题 | 中国科学院上海硅酸盐研究所 |
| 推荐引用方式 GB/T 7714 | Liu, Y,Wu, SM,Liu, YY,et al. Cathodic protected Mn2+ by NaxWO3 nanorods for stable magnetic resonance imaging-guided tumor photothermal therapy[J]. BIOMATERIALS,2020. |
| APA | Liu, Y.,Wu, SM.,Liu, YY.,Zhang, H.,Zhang, M.,...&Bu, WB.(2020).Cathodic protected Mn2+ by NaxWO3 nanorods for stable magnetic resonance imaging-guided tumor photothermal therapy.BIOMATERIALS. |
| MLA | Liu, Y,et al."Cathodic protected Mn2+ by NaxWO3 nanorods for stable magnetic resonance imaging-guided tumor photothermal therapy".BIOMATERIALS (2020). |
入库方式： OAI收割
来源：上海硅酸盐研究所
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