A Metal-Organic Framework (MOF) Fenton Nanoagent-Enabled Nanocatalytic Cancer Therapy in Synergy with Autophagy Inhibition
文献类型：期刊论文
| 作者 | Yang, BW; Ding, L; Yao, HL; Chen, Y; Shi, JL |
| 刊名 | ADVANCED MATERIALS
 |
| 出版日期 | 2020-03-01 |
| 期号 | 12 |
| ISSN号 | 0935-9648 |
| DOI | 10.1002/adma.201907152 |
| 文献子类 | Article |
| 英文摘要 | Nanocatalytic medicine has been developed recently to trigger intratumoral generation of highly toxic reactive oxygen species (ROS) for cancer therapy, which, unfortunately, suffers from compromised therapeutic efficacy due to a self-protective mechanism, autophagy, of cancer cells to mitigate oxidative damage. In this work, during the efforts of ROS generation by nanocatalytic medicine, a pharmacological autophagy inhibition strategy is implemented for augmenting ROS-induced oxidative damage for synergetic cancer therapy. An iron-containing metal-organic framework [MOF(Fe)] nanocatalyst as a peroxidase mimic is used to catalyze the generation of highly oxidizing center dot OH radicals specifically within cancer cells, while chloroquine is applied to deacidify lysosomes and inhibit autophagy, cutting off the self-protection pathway under severe oxidative stress. Cancer cells fail to extract their components to detoxicate and strengthen themselves, finally succumbing to the ROS-induced oxidative damage during nanocatalytic therapy. Both in vitro and in vivo results demonstrate the synergy between nanocatalytic therapy and autophagy inhibition, suggesting that such a combined strategy is applicable to amplify tumor-specific oxidative damage and may be informative to future design of therapeutic regimen. |
| WOS关键词 | HYDROGEN-PEROXIDE ; MODULATION ; BIOLOGY ; CELLS ; ROS ; POLY(ADP-RIBOSE) ; CHLOROQUINE ; MECHANISMS ; INDUCTION ; CHEMISTRY |
| WOS研究方向 | Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics |
| 语种 | 英语 |
| 出版者 | WILEY-V C H VERLAG GMBH |
| 源URL | [http://ir.sic.ac.cn/handle/331005/28309]  |
| 专题 | 中国科学院上海硅酸盐研究所 |
| 推荐引用方式 GB/T 7714 | Yang, BW,Ding, L,Yao, HL,et al. A Metal-Organic Framework (MOF) Fenton Nanoagent-Enabled Nanocatalytic Cancer Therapy in Synergy with Autophagy Inhibition[J]. ADVANCED MATERIALS,2020(12). |
| APA | Yang, BW,Ding, L,Yao, HL,Chen, Y,&Shi, JL.(2020).A Metal-Organic Framework (MOF) Fenton Nanoagent-Enabled Nanocatalytic Cancer Therapy in Synergy with Autophagy Inhibition.ADVANCED MATERIALS(12). |
| MLA | Yang, BW,et al."A Metal-Organic Framework (MOF) Fenton Nanoagent-Enabled Nanocatalytic Cancer Therapy in Synergy with Autophagy Inhibition".ADVANCED MATERIALS .12(2020). |
入库方式： OAI收割
来源：上海硅酸盐研究所
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