In Situ Catalytic Reaction for Solving the Aggregation of Hydrophobic Photosensitizers in Tumor
文献类型：期刊论文
| 作者 | Wang, CC; Zhao, PR; Jiang, DW; Yang, GL; Xue, YD; Tang, ZM; Zhang, M; Wang, H; Jiang, XW; Wu, YL |
| 刊名 | ACS APPLIED MATERIALS & INTERFACES
 |
| 出版日期 | 2020-02-05 |
| 期号 | 5页码:5624 |
| ISSN号 | 1944-8244 |
| DOI | 10.1021/acsami.9b21589 |
| 文献子类 | Article |
| 英文摘要 | The aggregation of hydrophobic photosensitizers limits the therapeutic effect of photodynamic therapy (PDT). Improving the hydrophilicity of photosensitizers can reduce their aggregation for enhancing PDT. Herein, a nanosystem (TPFcNP) is developed by a hydrophobic photosensitizer 5,10,15,20-tetralds(4-methacryloyloxyphenyl)-porphyrin (TMPP) containing multiple carbon-carbon double bonds and a ferrocene-containing amphiphilic block copolymer (PEG-b-PMAEFc), which catalyzes hydrogen peroxide (H2O2) to produce hydroxyl radicals ((OH)-O-center dot) in a tumor microenvironment by the Fenton reaction. The (OH)-O-center dot could catalyze the addition reaction between the carbon-carbon double bonds of TMPP and overexpressed water-soluble glutathione (GSH) in tumor cells, which greatly improves the hydrophilicity of photosensitizers and reduces their aggregation. Experiments in vitro and in vivo have proved that this strategy significantly enhances the therapeutic efficacy of PDT. Catalyzing intracellular reactions in situ by making use of the tumor microenvironment will open up a new opportunity to solve the aggregation of materials in the tumor for cancer treatment. |
| WOS关键词 | SUPEROXIDE RADICAL-ANION ; HYDROGEN-PEROXIDE ; PHOTODYNAMIC THERAPY ; GLUTATHIONE LEVELS ; NANOPARTICLES ; EFFICIENT ; CARBON ; NANOSYSTEM ; OXYGEN |
| WOS研究方向 | Science & Technology - Other Topics ; Materials Science |
| 语种 | 英语 |
| 出版者 | AMER CHEMICAL SOC |
| 源URL | [http://ir.sic.ac.cn/handle/331005/28316]  |
| 专题 | 中国科学院上海硅酸盐研究所 |
| 推荐引用方式 GB/T 7714 | Wang, CC,Zhao, PR,Jiang, DW,et al. In Situ Catalytic Reaction for Solving the Aggregation of Hydrophobic Photosensitizers in Tumor[J]. ACS APPLIED MATERIALS & INTERFACES,2020(5):5624. |
| APA | Wang, CC.,Zhao, PR.,Jiang, DW.,Yang, GL.,Xue, YD.,...&Bu, WB.(2020).In Situ Catalytic Reaction for Solving the Aggregation of Hydrophobic Photosensitizers in Tumor.ACS APPLIED MATERIALS & INTERFACES(5),5624. |
| MLA | Wang, CC,et al."In Situ Catalytic Reaction for Solving the Aggregation of Hydrophobic Photosensitizers in Tumor".ACS APPLIED MATERIALS & INTERFACES .5(2020):5624. |
入库方式： OAI收割
来源：上海硅酸盐研究所
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