Design and construction of a microporous (CO32-)-containing HA/beta-TCP biphasic ceramic as a novel bone graft material
文献类型：期刊论文
| 作者 | Dou, WX; Chen, HW; Chen, T; Zhu, QF; Jiang, DY; Xue, ZH; Wang, S; Wang, SH; Tang, WZ |
| 刊名 | MATERIALS RESEARCH EXPRESS
 |
| 出版日期 | 2020-02-01 |
| 期号 | 2 |
| DOI | 10.1088/2053-1591/ab6f3e |
| 文献子类 | Article |
| 英文摘要 | Biphasic calcium phosphate (BCP) ceramics, viewed as the first-line therapeutic materials in clinical practice, are still confronted with challenges such as undesirable biocompatibility and bioactivity given their structural and chemical deficiency. In this study, we designed a novel microporous CO32--containing BCP ceramic from Salmo salar bone in a CO2 atmosphere via two-step high-temperature sintering, and its physicochemical properties and biocompatibility were explored. A without CO32--BCP bioceramic material prepared in a single gas atmosphere was used as a comparison. The two scaffolds were characterized by x-ray diffraction (XRD), fourier transform infrared (FTIR) spectroscopy, and scanning electron microscopy (SEM), measured the size of its porosity and specific surface area by an instrument and in vitro cell experiment was used to test its biocompatibility. Such synthetic strategy endowed the BCP products with increased beta-tricalcium phosphate (beta-TCP) percentage from 37.18 wt% to 45.3 wt% (compared to BCP without CO32-), with the CO(3)(2-)content calculated to be 1.98 wt%, which is close to that in human bone tissue. The amount of CO32- incorporation, the a-axes of the lattice parameters have decreased significantly from 9.4845 nmto 9.2942 nm by Rietveld structure refinement. Especially, the novel CO32- containing BCP exhibits a lower degree of crystallinity than that without CO32-. In addition, the natural microporosity remarkably increased from 49.6% for BCP without CO32- to 64.06% for CO(3)(2-)containing BCP, and the specific surface area increased from 5.829 m(2) g(-1) to 17.161 m(2) g(-1). Besides, two materials were non-toxic to human bonemarrowmesenchymal stemcells (hBMSCs), and the CO(3)(2-)containing BCP had more factor expression in the early stage of osteogenesis induction, such as Runx2 and Smad 4. Overall, microporous CO(3)(2-)containing BCP were prepared via a simple preparation method from natural bone, combining the structural and chemical preponderance, as well as in vitro performance it should be considered as a promising biomaterial for further explorations in the fields of bone graft materials from natural bone to satisfy versatile clinical requirements. |
| WOS关键词 | CALCIUM-PHOSPHATE CERAMICS ; IN-VIVO ; HYDROXYAPATITE ; OSTEOINDUCTION ; FABRICATION ; SCAFFOLDS ; APATITE ; CELLS |
| WOS研究方向 | Materials Science |
| 语种 | 英语 |
| 出版者 | IOP PUBLISHING LTD |
| 源URL | [http://ir.sic.ac.cn/handle/331005/28324]  |
| 专题 | 中国科学院上海硅酸盐研究所 |
| 推荐引用方式 GB/T 7714 | Dou, WX,Chen, HW,Chen, T,et al. Design and construction of a microporous (CO32-)-containing HA/beta-TCP biphasic ceramic as a novel bone graft material[J]. MATERIALS RESEARCH EXPRESS,2020(2). |
| APA | Dou, WX.,Chen, HW.,Chen, T.,Zhu, QF.,Jiang, DY.,...&Tang, WZ.(2020).Design and construction of a microporous (CO32-)-containing HA/beta-TCP biphasic ceramic as a novel bone graft material.MATERIALS RESEARCH EXPRESS(2). |
| MLA | Dou, WX,et al."Design and construction of a microporous (CO32-)-containing HA/beta-TCP biphasic ceramic as a novel bone graft material".MATERIALS RESEARCH EXPRESS .2(2020). |
入库方式： OAI收割
来源：上海硅酸盐研究所
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