Intelligent Nanocomposites with Intrinsic Blood-Brain-Barrier Crossing Ability Designed for Highly Specific MR Imaging and Sonodynamic Therapy of Glioblastoma
文献类型：期刊论文
| 作者 | Liang, KC; Li, ZC; Luo, Y; Zhang, QH; Yin, FF; Xu, LJ; Chen, HR; Wang, H |
| 刊名 | SMALL
 |
| 出版日期 | 2020-02-01 |
| 期号 | 8 |
| ISSN号 | 1613-6810 |
| DOI | 10.1002/smll.201906985 |
| 文献子类 | Article |
| 英文摘要 | The blood-brain barrier (BBB) is the most important obstacle to improving the clinical outcomes of diagnosis and therapy of glioblastoma. Thus, the development of a novel nanoplatform that can efficiently traverse the BBB and achieve both precise diagnosis and therapy is of great importance. Herein, an intelligent nanoplatform based on holo-transferrin (holo-Tf) with in situ growth of MnO2 nanocrystals is constructed via a reformative mild biomineralization process. Furthermore, protoporphyrin (ppIX), acting as a sonosensitizer, is then conjugated into holo-Tf to obtain MnO2@Tf-ppIX nanoparticles (TMP). Because of the functional inheritance of holo-Tf during fabrication, TMP can effectively traverse the BBB for highly specific magnetic resonance (MR) imaging of orthotopic glioblastoma. Clear suppression of tumor growth in a C6 tumor xenograft model is achieved via sonodynamic therapy. Importantly, the experiments also indicate that the TMP nanoplatform has satisfactory biocompatibility and biosafety, which favors potential clinical translation. |
| WOS关键词 | NANOPARTICLES ; TRANSFERRIN ; TUMOR ; TEMOZOLOMIDE ; DELIVERY ; PLASMA |
| WOS研究方向 | Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics |
| 语种 | 英语 |
| 出版者 | WILEY-V C H VERLAG GMBH |
| 源URL | [http://ir.sic.ac.cn/handle/331005/28356]  |
| 专题 | 中国科学院上海硅酸盐研究所 |
| 推荐引用方式 GB/T 7714 | Liang, KC,Li, ZC,Luo, Y,et al. Intelligent Nanocomposites with Intrinsic Blood-Brain-Barrier Crossing Ability Designed for Highly Specific MR Imaging and Sonodynamic Therapy of Glioblastoma[J]. SMALL,2020(8). |
| APA | Liang, KC.,Li, ZC.,Luo, Y.,Zhang, QH.,Yin, FF.,...&Wang, H.(2020).Intelligent Nanocomposites with Intrinsic Blood-Brain-Barrier Crossing Ability Designed for Highly Specific MR Imaging and Sonodynamic Therapy of Glioblastoma.SMALL(8). |
| MLA | Liang, KC,et al."Intelligent Nanocomposites with Intrinsic Blood-Brain-Barrier Crossing Ability Designed for Highly Specific MR Imaging and Sonodynamic Therapy of Glioblastoma".SMALL .8(2020). |
入库方式： OAI收割
来源：上海硅酸盐研究所
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