Augmenting Tumor-Starvation Therapy by Cancer Cell Autophagy Inhibition
文献类型：期刊论文
| 作者 | Yang, BW; Ding, L; Chen, Y; Shi, JL |
| 刊名 | ADVANCED SCIENCE
 |
| 出版日期 | 2020-03-01 |
| 期号 | 6 |
| DOI | 10.1002/advs.201902847 |
| 文献子类 | Article |
| 英文摘要 | It was recently recognized that cancer therapeutic efficacy may be greatly compromised by an intrinsic protective mechanism called autophagy, by which cancer cells survive in harsh conditions such as starvation. Here, a synergetic strategy is described for cancer treatment by suppressing such a protective mechanism for augmenting tumor-starvation therapy. The synergetic therapy is achieved by restraining glucose metabolism using an antiglycolytic agent to predispose cancer cells to severe energy deprivation; concurrently the downstream autophagic flux and compensatory energy supplies are blocked by the autophagy inhibitor black phosphorus nanosheet. Cancer cells fail to extract their own nutrient to feed themselves, finally succumbing to therapeutic interventions and starving to death. Both in vitro and in vivo results evidence the cooperative effect between the autophagy inhibitor and antiglycolytic agent, which leads to remarkable synergetic antineoplastic outcome. It is expected that such a combinational approach by concurrently blocking exogenous and endogenous nutrition supplies will be beneficial to the design of effective tumor-specific cancer therapies in the future. |
| WOS关键词 | 2-DEOXY-D-GLUCOSE ; GLYCOLYSIS ; METABOLISM ; INDUCTION ; 2-DEOXYGLUCOSE |
| WOS研究方向 | Chemistry ; Science & Technology - Other Topics ; Materials Science |
| 语种 | 英语 |
| 出版者 | WILEY |
| 源URL | [http://ir.sic.ac.cn/handle/331005/28361]  |
| 专题 | 中国科学院上海硅酸盐研究所 |
| 推荐引用方式 GB/T 7714 | Yang, BW,Ding, L,Chen, Y,et al. Augmenting Tumor-Starvation Therapy by Cancer Cell Autophagy Inhibition[J]. ADVANCED SCIENCE,2020(6). |
| APA | Yang, BW,Ding, L,Chen, Y,&Shi, JL.(2020).Augmenting Tumor-Starvation Therapy by Cancer Cell Autophagy Inhibition.ADVANCED SCIENCE(6). |
| MLA | Yang, BW,et al."Augmenting Tumor-Starvation Therapy by Cancer Cell Autophagy Inhibition".ADVANCED SCIENCE .6(2020). |
入库方式： OAI收割
来源：上海硅酸盐研究所
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