Bioinspired Biomaterials with a Brick-and-Mortar Microstructure Combining Mechanical and Biological Performance
文献类型：期刊论文
| 作者 | Li, T; Ma, B; Xue, JM; Zhai, D; Zhao, PY; Chang, J; Wu, CT |
| 刊名 | ADVANCED HEALTHCARE MATERIALS
 |
| 出版日期 | 2020-02-01 |
| 期号 | 4 |
| ISSN号 | 2192-2640 |
| DOI | 10.1002/adhm.201901211 |
| 文献子类 | Article |
| 英文摘要 | The fabrication of bone regeneration biomaterials, which simultaneously possess superior mechanical performances and excellent bioactivity, remains challenging because these properties are usually mutually exclusive. Herein, inspired by the brick-and-mortar architecture of nacre, lamellar silicate-based bioceramic composites are successfully prepared by constructing orderly layered bioceramics infiltrated with a biomedical resin interlayer via the bidirectional freezing technique. The lamellar composites possess high strength and proper Young's moduli, which match with human cortical bone. Furthermore, the lamellar composites can release bioactive ions with a controlled profile, which significantly enhance the cell proliferation of both rabbit bone mesenchymal stem cells and periodontal ligament cells in vitro. Moreover, with the degradation of silicate bioceramics in vivo, newly formed bone tissue can grow into the materials to present the bioceramic/new bone/resin sandwich-like lamellar microstructure. The silicate-based bioceramic composites with brick-and-mortar architecture represent an excellent biomaterial in combination of superior mechanical performances matching that of human cortical bone, and excellent bioactivity for potential load-bearing bone regeneration. |
| WOS关键词 | HIGH-STRENGTH ; COMPOSITE ; HYDROXYAPATITE ; BIOCERAMICS ; SCAFFOLDS ; STIFFNESS ; NACRE ; TOUGH |
| WOS研究方向 | Engineering ; Science & Technology - Other Topics ; Materials Science |
| 语种 | 英语 |
| 出版者 | WILEY |
| 源URL | [http://ir.sic.ac.cn/handle/331005/28374]  |
| 专题 | 中国科学院上海硅酸盐研究所 |
| 推荐引用方式 GB/T 7714 | Li, T,Ma, B,Xue, JM,et al. Bioinspired Biomaterials with a Brick-and-Mortar Microstructure Combining Mechanical and Biological Performance[J]. ADVANCED HEALTHCARE MATERIALS,2020(4). |
| APA | Li, T.,Ma, B.,Xue, JM.,Zhai, D.,Zhao, PY.,...&Wu, CT.(2020).Bioinspired Biomaterials with a Brick-and-Mortar Microstructure Combining Mechanical and Biological Performance.ADVANCED HEALTHCARE MATERIALS(4). |
| MLA | Li, T,et al."Bioinspired Biomaterials with a Brick-and-Mortar Microstructure Combining Mechanical and Biological Performance".ADVANCED HEALTHCARE MATERIALS .4(2020). |
入库方式： OAI收割
来源：上海硅酸盐研究所
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