Improved cellular bioactivity by heparin immobilization on polycarbonate film via an aminolysis modification for potential tendon repair
文献类型：期刊论文
| 作者 | Guo, JS; Li, K; Ning, CQ; Liu, XY |
| 刊名 | INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
 |
| 出版日期 | 2020 |
| 页码 | 835 |
| ISSN号 | 0141-8130 |
| DOI | 10.1016/j.ijbiomac.2019.09.136 |
| 文献子类 | Article |
| 英文摘要 | Tendon repair was an important part during tendon to bone healing. In the present study, heparin molecules were immobilized on the aminolyzed PCL surface to improve the cellular bioactivity for potential tendon repair. The effects of heparin immobilization on protein adsorption behavior and cellular bioactivity of NIH3T3 and ATDC5 cells were investigated. The results were shown as follows: 1. Heparin molecules could be effectively immobilized on the PCL surface through an aminolysis modification. 2. PCL films exhibited a more negative surface after heparin immobilization. The existence of heparin enhanced the adsorption of proteins. 3. Heparin immobilized PCL sample improved the attachment and proliferation of NIH3T3 and ATDC5 cells, also enhanced the secretion of collagen and glycosaminoglycans. (C) 2019 Elsevier B.V. All rights reserved. |
| WOS关键词 | MOLECULAR-WEIGHT HEPARIN ; CHONDROCYTE ADHESION ; PROTEIN ; SURFACE ; COLLAGEN ; PROLIFERATION ; INTERCALATION ; KINETICS ; SURGERY ; SULFATE |
| WOS研究方向 | Biochemistry & Molecular Biology ; Chemistry ; Polymer Science |
| 语种 | 英语 |
| 出版者 | ELSEVIER |
| 源URL | [http://ir.sic.ac.cn/handle/331005/28396]  |
| 专题 | 中国科学院上海硅酸盐研究所 |
| 推荐引用方式 GB/T 7714 | Guo, JS,Li, K,Ning, CQ,et al. Improved cellular bioactivity by heparin immobilization on polycarbonate film via an aminolysis modification for potential tendon repair[J]. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,2020:835. |
| APA | Guo, JS,Li, K,Ning, CQ,&Liu, XY.(2020).Improved cellular bioactivity by heparin immobilization on polycarbonate film via an aminolysis modification for potential tendon repair.INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,835. |
| MLA | Guo, JS,et al."Improved cellular bioactivity by heparin immobilization on polycarbonate film via an aminolysis modification for potential tendon repair".INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2020):835. |
入库方式： OAI收割
来源：上海硅酸盐研究所
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