Combined Magnetic Hyperthermia and Immune Therapy for Primary and Metastatic Tumor Treatments
文献类型：期刊论文
| 作者 | Pan, J; Hu, P; Guo, YD; Hao, JN; Ni, DL; Xu, YY; Bao, QQ; Yao, HL; Wei, CY; Wu, QS |
| 刊名 | ACS NANO
 |
| 出版日期 | 2020 |
| 期号 | 1页码:1033 |
| ISSN号 | 1936-0851 |
| DOI | 10.1021/acsnano.9b08550 |
| 文献子类 | Article |
| 英文摘要 | Cancer immunotherapy shows promising potential in future cancer treatment but unfortunately is clinically unsatisfactory due to the low therapeutic efficacy and the possible severe immunotoxicity. Here we show a combined magnetic hyperthermia therapy (MHT) and checkpoint blockade immunotherapy for both primary tumor ablation and mimetic metastatic tumor inhibition. Monodispersed, high-performance superparamagnetic CoFe2O4@MnFe2O4 nanoparticles were synthesized and used for effective MHT-induced thermal ablation of primary tumors. Simultaneously, numerous tumor-associated antigens were produced to promote the maturation and activation of dendritic cells (DCs) and cytotoxic T cells for effective immunotherapy of distant mimetic metastatic tumors in a tumor-bearing mice model. The combined MHT and checkpoint blockade immunotherapy demonstrate the great potentials in the fight against both primary and metastatic tumors. |
| WOS关键词 | PHOTOTHERMAL THERAPY ; CHECKPOINT BLOCKADE ; ACQUIRED-RESISTANCE ; ANTITUMOR IMMUNITY ; CANCER ; IMMUNOTHERAPY ; NANOPARTICLES ; PD-L1 ; CRYOABLATION ; COMBINATION |
| WOS研究方向 | Chemistry ; Science & Technology - Other Topics ; Materials Science |
| 语种 | 英语 |
| 出版者 | AMER CHEMICAL SOC |
| 源URL | [http://ir.sic.ac.cn/handle/331005/28397]  |
| 专题 | 中国科学院上海硅酸盐研究所 |
| 推荐引用方式 GB/T 7714 | Pan, J,Hu, P,Guo, YD,et al. Combined Magnetic Hyperthermia and Immune Therapy for Primary and Metastatic Tumor Treatments[J]. ACS NANO,2020(1):1033. |
| APA | Pan, J.,Hu, P.,Guo, YD.,Hao, JN.,Ni, DL.,...&Shi, JL.(2020).Combined Magnetic Hyperthermia and Immune Therapy for Primary and Metastatic Tumor Treatments.ACS NANO(1),1033. |
| MLA | Pan, J,et al."Combined Magnetic Hyperthermia and Immune Therapy for Primary and Metastatic Tumor Treatments".ACS NANO .1(2020):1033. |
入库方式： OAI收割
来源：上海硅酸盐研究所
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