Catalytic oxidation of biomass-derived 1,2-propanediol to valuable lactic acid was investigated over various Cu-modified Au supported on Mg-Al hydrotalcite (HT). Compared to those of individual Au-HT, better catalytic performance was achieved over the Cu-modified Au-HT catalysts, mainly due to the suppression of by-product generation. The structural properties of the Cu-Au/HT catalysts were determined by XRD, SEM, HRTEM, and N(2)physical adsorption, and a strong interaction was discovered in the Cu-modified Au-HT catalysts. A control experiment verified that the secondary hydroxyl in 1,2-propanediol is unreactive over Au/HT catalysts modified with Cu, which intensively inhibited the generation of the main by-products, formic acid and acetic acid. These findings provided useful guidance for the design of more efficient and stable nano-catalysts for oxidizing glycols to organic acids containing hydroxides.