Bioinspired Fabrication of Calcium-Doped TiP Coating with Nanofibrous Microstructure to Accelerate Osseointegration
文献类型：期刊论文
| 作者 | Cai, Bianyun; Tan, Peijie; Jiang, Nan; Guo, Zhijun; Ay, Birol; Li, Shujun; Hou, Yi; Li, Yubao; You, Yanjun; Zhang, Li |
| 刊名 | BIOCONJUGATE CHEMISTRY
 |
| 出版日期 | 2020-06-01 |
| 卷号 | 31期号:6页码:1641-1650 |
| DOI | 10.1021/acs.bioconjchem.0c00201 |
| 英文摘要 | Bioinspired by the morphology of osteoclast-resorbed bone surfaces, we prepared a calcium-doped titanium phosphate (Ca-TiP) coating, which consists of a nanofibrous network, on titanium (Ti) substrate via a simple two-step hydrothermal method, trying to mimic natural bone compositionally and microstructurally. The in vitro studies show that the Ca-TiP coating with synergistic features of nanofibrous biomimetic topography and surface chemistry could elicit intensively osteogenic behavior and responses including enhanced cell adhesion, spreading, and proliferation as well as alkaline phosphatase (ALP) activity and up-regulated expression of bone-related genes, which inevitably benefit the formation of new bone and the quality of osseointegration. When the two control groups are compared in vivo, the significantly improved new bone formation in the early stage and the much stronger interfacial bonding with the surrounding bone for Ca-TiP coating suggest that Ca-TiP coating modified Ti implants hold great potential for orthopedic and dental applications. |
| WOS记录号 | WOS:000542926300008 |
| 源URL | [http://ir.imr.ac.cn/handle/321006/82804]  |
| 专题 | 金属研究所_中国科学院金属研究所 |
| 推荐引用方式 GB/T 7714 | Cai, Bianyun,Tan, Peijie,Jiang, Nan,et al. Bioinspired Fabrication of Calcium-Doped TiP Coating with Nanofibrous Microstructure to Accelerate Osseointegration[J]. BIOCONJUGATE CHEMISTRY,2020,31(6):1641-1650. |
| APA | Cai, Bianyun.,Tan, Peijie.,Jiang, Nan.,Guo, Zhijun.,Ay, Birol.,...&Zhu, Songsong.(2020).Bioinspired Fabrication of Calcium-Doped TiP Coating with Nanofibrous Microstructure to Accelerate Osseointegration.BIOCONJUGATE CHEMISTRY,31(6),1641-1650. |
| MLA | Cai, Bianyun,et al."Bioinspired Fabrication of Calcium-Doped TiP Coating with Nanofibrous Microstructure to Accelerate Osseointegration".BIOCONJUGATE CHEMISTRY 31.6(2020):1641-1650. |
入库方式： OAI收割
来源：金属研究所
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