中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
Modes of genetic adaptations underlying functional innovations in the rumen

文献类型:期刊论文

作者Pan, Xiangyu2; Cai, Yudong2; Li, Zongjun2; Chen, Xianqing3; Heller, Rasmus4; Wang, Nini2; Wang, Yu2; Zhao, Chen2; Wang, Yong5,6,7; Xu, Han2
刊名SCIENCE CHINA-LIFE SCIENCES
出版日期2020-11-05
页码21
ISSN号1674-7305
关键词rumen innovations comparative transcriptomics comparative genomics evo-devo evolution of organs
DOI10.1007/s11427-020-1828-8
英文摘要The rumen is the hallmark organ of ruminants and hosts a diverse ecosystem of microorganisms that facilitates efficient digestion of plant fibers. We analyzed 897 transcriptomes from three Cetartiodactyla lineages: ruminants, camels and cetaceans, as well as data from ruminant comparative genomics and functional assays to explore the genetic basis of rumen functional innovations. We identified genes with relatively high expression in the rumen, of which many appeared to be recruited from other tissues. These genes show functional enrichment in ketone body metabolism, regulation of microbial community, and epithelium absorption, which are the most prominent biological processes involved in rumen innovations. Several modes of genetic change underlying rumen functional innovations were uncovered, including coding mutations, genes newly evolved, and changes of regulatory elements. We validated that the key ketogenesis rate-limiting gene (HMGCS2) with five ruminant-specific mutations was under positive selection and exhibits higher synthesis activity than those of other mammals. Two newly evolved genes (LYZ1 and DEFB1) are resistant to Gram-positive bacteria and thereby may regulate microbial community equilibrium. Furthermore, we confirmed that the changes of regulatory elements accounted for the majority of rumen gene recruitment. These results greatly improve our understanding of rumen evolution and organ evo-devo in general.
资助项目National Natural Science Foundation of China[31822052] ; National Natural Science Foundation of China[31572381] ; National Natural Science Foundation of China[31660644] ; National Natural Science Foundation of China[41422604] ; National Thousand Youth Talents Plan ; Villum Foundation[VKR 023447] ; Independent Research Fund Denmark[8049-00098B]
WOS研究方向Life Sciences & Biomedicine - Other Topics
语种英语
出版者SCIENCE PRESS
WOS记录号WOS:000587977700002
源URL[http://ir.amss.ac.cn/handle/2S8OKBNM/52421]  
专题应用数学研究所
通讯作者Wang, Wen; Jiang, Yu
作者单位1.Yangzhou Univ, Coll Anim Sci & Technol, Yangzhou 225009, Jiangsu, Peoples R China
2.Northwest A&F Univ, Coll Anim Sci & Technol, Key Lab Anim Genet Breeding & Reprod Shaanxi Prov, Yangling 712100, Shaanxi, Peoples R China
3.Northwestern Polytech Univ, Sch Ecol & Environm, Xian 710072, Peoples R China
4.Univ Copenhagen, Dept Biol, Sect Computat & RNA Biol, DK-2100 Copenhagen, Denmark
5.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
6.Chinese Acad Sci, Ctr Excellence Anim Evolut & Genet, Kunming 650223, Yunnan, Peoples R China
7.Chinese Acad Sci, Acad Math & Syst Sci, CEMS, NCMIS,MDIS, Beijing 100080, Peoples R China
8.Chinese Acad Sci, Inst Deep Sea Sci & Engn, Marine Mammal & Marine Bioacoust Lab, Sanya 572000, Peoples R China
9.Shihezi Univ, Coll Life Sci, Shihezi 832003, Peoples R China
10.Guangxi Univ, Coll Anim Sci & Technol, State Key Lab Conservat & Utilizat Subtrop Agrobi, Nanning 530005, Peoples R China
推荐引用方式
GB/T 7714
Pan, Xiangyu,Cai, Yudong,Li, Zongjun,et al. Modes of genetic adaptations underlying functional innovations in the rumen[J]. SCIENCE CHINA-LIFE SCIENCES,2020:21.
APA Pan, Xiangyu.,Cai, Yudong.,Li, Zongjun.,Chen, Xianqing.,Heller, Rasmus.,...&Jiang, Yu.(2020).Modes of genetic adaptations underlying functional innovations in the rumen.SCIENCE CHINA-LIFE SCIENCES,21.
MLA Pan, Xiangyu,et al."Modes of genetic adaptations underlying functional innovations in the rumen".SCIENCE CHINA-LIFE SCIENCES (2020):21.

入库方式: OAI收割

来源:数学与系统科学研究院

浏览0
下载0
收藏0
其他版本

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。