Diverse Types of Diterpenoids with an Aromatized C Ring from the Twigs of Podocarpus imbricatus
文献类型：期刊论文
| 作者 | Zhou, Bin1,2; Ren, Yu-Hao1,2; Han, Ying-Shan3; Mesplede, Thibault3; Yue, Jian-Min1,2
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| 刊名 | JOURNAL OF NATURAL PRODUCTS
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| 出版日期 | 2020-08-28 |
| 卷号 | 83期号:8页码:2416-2424 |
| ISSN号 | 0163-3864 |
| DOI | 10.1021/acs.jnatprod.0c00291 |
| 通讯作者 | Yue, Jian-Min(jmyue@simm.ac.cn) |
| 英文摘要 | An ethanol extract of the powdered twigs of Podocarpus imbricatus afforded 14 new diterpenoids (1-14), which all share an aromatized C ring. These isolates belong to five diterpenoid types that include abietanes (1-3), semperviranes (4-9), totaranes (10-12), a C-17 norabietane (13), and an icetexane (14). Their structures were assigned mainly by analysis of the spectroscopic data, and the absolute configuration of 1 was determined by X-ray crystallography. A biosynthetic pathway for five of the biogenetically related types of diterpenoids was proposed. Compound 7 showed moderate inhibitory activity against Zika virus with an IC50 value of 2.5 mu M. |
| WOS关键词 | ABIETANE DITERPENOIDS ; ZIKA VIRUS |
| 资助项目 | National Natural Science Foundation[21532007] ; Drug Innovation Major Project, MOST[2018ZX09711001-001-005] ; Biological Resources Program, CAS, of People's Republic of China[KFJ-BRP-008] |
| WOS研究方向 | Plant Sciences ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000566765000012 |
| 出版者 | AMER CHEMICAL SOC |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/291086]  |
| 专题 | 新药研究国家重点实验室 |
| 通讯作者 | Yue, Jian-Min |
| 作者单位 | 1.Chinese Acad Sci, State Key Lab Drug Res, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 3.McGill Univ, AIDS Ctr, Lady Davis Inst Med Res, Jewish Gen Hosp, Montreal, PQ H3T 1E2, Canada |
| 推荐引用方式 GB/T 7714 | Zhou, Bin,Ren, Yu-Hao,Han, Ying-Shan,et al. Diverse Types of Diterpenoids with an Aromatized C Ring from the Twigs of Podocarpus imbricatus[J]. JOURNAL OF NATURAL PRODUCTS,2020,83(8):2416-2424. |
| APA | Zhou, Bin,Ren, Yu-Hao,Han, Ying-Shan,Mesplede, Thibault,&Yue, Jian-Min.(2020).Diverse Types of Diterpenoids with an Aromatized C Ring from the Twigs of Podocarpus imbricatus.JOURNAL OF NATURAL PRODUCTS,83(8),2416-2424. |
| MLA | Zhou, Bin,et al."Diverse Types of Diterpenoids with an Aromatized C Ring from the Twigs of Podocarpus imbricatus".JOURNAL OF NATURAL PRODUCTS 83.8(2020):2416-2424. |
入库方式： OAI收割
来源：上海药物研究所
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