Manipulating the Click Reactivity of Dibenzoazacyclooctynes: From Azide Click Component to Caged Acylation Reagent by Silver Catalysis
文献类型：期刊论文
| 作者 | Shi, Wei1,2,3; Tang, Feng1,3; Ao, Jiwei1; Yu, Qun1; Liu, Junjie1; Tang, Yubo1; Jiang, Bofeng1; Ren, Xuelian1; Huang, He1,2; Yang, Weibo1,2,3
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| 刊名 | ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
 |
| 出版日期 | 2020-08-31 |
| 页码 | 6 |
| ISSN号 | 1433-7851 |
| 关键词 | acylation click chemistry peptides rearrangements silver |
| DOI | 10.1002/anie.202009408 |
| 通讯作者 | Yang, Weibo(yweibo@simm.ac.cn) ; Huang, Wei(huangwei@simm.ac.cn) |
| 英文摘要 | Strain-promoted azide-alkyne cycloaddition using dibenzoazacyclooctyne (DBCO) is widely applied in copper-free bioorthogonal reactions. Reported here is the efficient acid-promoted rearrangement and silver-catalyzed amidation of DBCO, which alters its click reactivity robustly. In the switched click reaction, DBCO, as a caged acylation reagent, enables rapid peptide/protein modification after decaging facilitated by silver catalysts, rendering site-specific conjugation of an IgG antibody by a Fc-targeting peptide. |
| WOS关键词 | COPPER-FREE ; CYCLOADDITION ; IGG |
| 资助项目 | National Natural Science Foundation of China (NNSFC)[21877116] ; National Natural Science Foundation of China (NNSFC)[21702217] ; National Science & Technology Major Project Key New Drug Creation and Manufacturing Program of China[2018ZX09711002-006] ; National Science & Technology Major Project Key New Drug Creation and Manufacturing Program of China[2019ZX09721001] ; Shanghai-Technology Innovation Action Plan[18JC1415300] |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| 出版者 | WILEY-V C H VERLAG GMBH |
| WOS记录号 | WOS:000567290000001 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/291119]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Yang, Weibo; Huang, Wei |
| 作者单位 | 1.Chinese Acad Sci, CAS Ctr Excellence Mol Cell Sci, Ctr Biotherapeut Discovery Res, Shanghai Inst Mat Med,CAS Key Lab Receptor Res, 555 Zuchongzhi Rd, Shanghai 201203, Peoples R China 2.Univ Chinese Acad Sci, 19A Yuquan Rd, Beijing 100049, Peoples R China 3.Univ Chinese Acad Sci, Hangzhou Inst Adv Study, Sch Pharmaceut Sci & Technol, Hangzhou 310024, Peoples R China |
| 推荐引用方式 GB/T 7714 | Shi, Wei,Tang, Feng,Ao, Jiwei,et al. Manipulating the Click Reactivity of Dibenzoazacyclooctynes: From Azide Click Component to Caged Acylation Reagent by Silver Catalysis[J]. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION,2020:6. |
| APA | Shi, Wei.,Tang, Feng.,Ao, Jiwei.,Yu, Qun.,Liu, Junjie.,...&Huang, Wei.(2020).Manipulating the Click Reactivity of Dibenzoazacyclooctynes: From Azide Click Component to Caged Acylation Reagent by Silver Catalysis.ANGEWANDTE CHEMIE-INTERNATIONAL EDITION,6. |
| MLA | Shi, Wei,et al."Manipulating the Click Reactivity of Dibenzoazacyclooctynes: From Azide Click Component to Caged Acylation Reagent by Silver Catalysis".ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2020):6. |
入库方式： OAI收割
来源：上海药物研究所
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