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Recent Progress in the Design and Application of Supramolecular Peptide Hydrogels in Cancer Therapy

文献类型：期刊论文

作者Cai, Ying1,2; Zheng, Chao1,3; Xiong, Fengqin1,3; Ran, Wei1,2; Zhai, Yihui1,2; Zhu, Helen H.4,5; Wang, Hao3; Li, Yaping1,2; Zhang, Pengcheng1,2,6
刊名ADVANCED HEALTHCARE MATERIALS
出版日期2020-09-16
页码23
关键词cancer hydrogels local therapy peptides supramolecular self-assembly
ISSN号2192-2640
DOI10.1002/adhm.202001239
通讯作者Li, Yaping(ypli@simm.ac.cn) ; Zhang, Pengcheng(pzhang@simm.ac.cn)
英文摘要Supramolecular peptide hydrogel (SPH) is a class of biomaterials self-assembled from peptide-based gelators through non-covalent interactions. Among many of its biomedical applications, the potential of SPH in cancer therapy has been vastly explored in the past decade, taking advantage of its good biocompatibility, multifunctionality, and injectability. SPHs can exert localized cancer therapy and induce systemic anticancer immunity to prevent tumor recurrence, depending on the design of SPH. This review first gives a brief introduction to SPH and then outlines the major types of peptide-based gelators that have been developed so far. The methodologies to tune the physicochemical properties and biological activities are summarized. The recent advances of SPH in cancer therapy as carriers, prodrugs, or drugs are highlighted. Finally, the clinical translation potential and main challenges in this field are also discussed.
WOS关键词EXTRACELLULAR-MATRIX ; CONTROLLED-RELEASE ; RATIONAL DESIGN ; AMPHIPHILE NANOFIBERS ; MECHANICAL RIGIDITY ; AROMATIC PEPTIDE ; DELIVERY ; CELL ; PROTEIN ; DOXORUBICIN
资助项目National Natural Science Foundation of China[31870995] ; National Natural Science Foundation of China[81690265] ; National Natural Science Foundation of China[81671808] ; National Natural Science Foundation of China[81630052] ; Youth Innovation Promotion Association of CAS[2017335] ; SA-SIBS Scholarship Program
WOS研究方向Engineering ; Science & Technology - Other Topics ; Materials Science
语种英语
WOS记录号WOS:000569391000001
出版者WILEY
源URL[http://119.78.100.183/handle/2S10ELR8/291141]  
专题新药研究国家重点实验室
通讯作者Li, Yaping; Zhang, Pengcheng
作者单位1.Chinese Acad Sci, Shanghai Inst Materia Med, State Key Lab Drug Res & Ctr Pharmaceut, Shanghai 201203, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
3.China State Inst Pharmaceut Ind, Shanghai 200040, Peoples R China
4.Shanghai Jiao Tong Univ, State Key Lab Oncogenes & Related Genes, Renji Med X Stem Cell Res Ctr, Dept Urol,Ren Ji Hosp,Sch Med, Shanghai 200127, Peoples R China
5.Shanghai Jiao Tong Univ, Sch Biomed Engn, Shanghai 200127, Peoples R China
6.Yantai Inst Mat Medica, Yantai Key Lab Nanomed & Adv Preparat, Yantai 264000, Shandong, Peoples R China
推荐引用方式
GB/T 7714		 Cai, Ying,Zheng, Chao,Xiong, Fengqin,et al. Recent Progress in the Design and Application of Supramolecular Peptide Hydrogels in Cancer Therapy[J]. ADVANCED HEALTHCARE MATERIALS,2020:23.
APA Cai, Ying.,Zheng, Chao.,Xiong, Fengqin.,Ran, Wei.,Zhai, Yihui.,...&Zhang, Pengcheng.(2020).Recent Progress in the Design and Application of Supramolecular Peptide Hydrogels in Cancer Therapy.ADVANCED HEALTHCARE MATERIALS,23.
MLA Cai, Ying,et al."Recent Progress in the Design and Application of Supramolecular Peptide Hydrogels in Cancer Therapy".ADVANCED HEALTHCARE MATERIALS (2020):23.

入库方式： OAI收割

来源：上海药物研究所

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