Paeonol loaded cyclodextrin metal-organic framework particles for treatment of acute lung injury via inhalation
文献类型：期刊论文
| 作者 | Li, Haiyan1,3 ; Zhu, Jie2; Wang, Caifen1; Qin, Wei1; Hu, Xiaoxiao1; Tong, Jiabin4; Yu, Lin1; Zhang, Guoqing1,2; Ren, Xiaohong1; Li, Zegeng2,4
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| 刊名 | INTERNATIONAL JOURNAL OF PHARMACEUTICS
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| 出版日期 | 2020-09-25 |
| 卷号 | 587页码:11 |
| 关键词 | Targeted pulmonary delivery Cyclodextrin metal-organic frameworks Dry powder inhalers Paeonol Acute lung injury |
| ISSN号 | 0378-5173 |
| DOI | 10.1016/j.ijpharm.2020.119649 |
| 通讯作者 | Li, Haiyan(li6609@126.com) |
| 英文摘要 | Administration of drugs via inhalation can overcome issues related to poor water solubility, low absorption or bioavailability associated with oral administration. In the current study we used gamma-cyclodextrin metal organic frameworks (CD-MOFs) of inhalable particle sizes, with cubic morphologies and favorable aerodynamic properties to achieve targeted pulmonary drug delivery via dry powder inhalers. The active natural compound, paeonol (PAE), was chosen as a model drug for treatment of acute lung injury (ALI). After loading of PAE into CD-MOF particles of inhalable sizes, PAE was rapidly released in phosphate buffer (pH = 7.4; 90% within 30 min) and in vivo experiments. After mixing with coarse and fine lactose (Inhalac (R) 230: Inhalac (R) 400: PAE-CD-MOF = 40:10:50, w/w/w), paeonol had a high fine particle fraction (FPF) (28.59%). Atom force microscopy was used to assess surface roughness and adhesive force. In vivo inhalation of PAE-CD-MOF dry powder inhaler by rat demonstrated rapid absorption (tmax of 4.0 min) and high absolute bioavailability (71%) of PAE, highlighting significant improvements in absorption and bioavailability of PAE when compared with oral administration (C-max and absolute bioavailability increased 6.5 and 9.3 folds, respectively). Results of in vivo experiments were consistent with cellular permeability studies (after loading into CD-MOF, the permeability of PAE improved about 5 folds in comparison to the pure PAE). Finally, the efficacy of inhaled PAE for ALI was validated by histopathological examination and via reduced levels of inflammatory factors observed in rat plasma. Overall, targeted pulmonary delivery of paeonol by inhaled PAE-CD-MOF particles appears to be promising method of delivery for treatment of ALI. |
| WOS关键词 | DRUG-DELIVERY ; DRY POWDER ; CD-MOF ; NANOPARTICLES ; MICROPARTICLES |
| 资助项目 | Key Program for International Science and Technology Cooperation Projects of China[2016YFE0125100] ; Key Program for International Science and Technology Cooperation Projects of China[2019YFE020185] ; Opening Project of Zhejiang Provincial First-rate Subject (Chinese Traditional Medicine) from Zhejiang Chinese Medical University[Ya2017006] ; Research Foundation of the Shanghai Institute of Materia Medica[CASIMM0120182001] |
| WOS研究方向 | Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000568785100013 |
| 出版者 | ELSEVIER |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/291172]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Li, Haiyan |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, Ctr Drug Delivery Syst, 501 Haike Rd, Shanghai 201203, Peoples R China 2.Anhui Univ Chinese Med, Hefei 230012, Peoples R China 3.Zhejiang Chinese Med Univ, Sch Pharm, Hangzhou 310053, Peoples R China 4.Anhui Univ Chinese Med, Affiliated Hosp 1, Hefei 230031, Peoples R China 5.Natl Inst Food & Drug Control, NMPA Key Lab Qual Res & Evaluat Pharmaceut Excipi, 2 Tiantan Xili, Beijing 100050, Peoples R China |
| 推荐引用方式 GB/T 7714 | Li, Haiyan,Zhu, Jie,Wang, Caifen,et al. Paeonol loaded cyclodextrin metal-organic framework particles for treatment of acute lung injury via inhalation[J]. INTERNATIONAL JOURNAL OF PHARMACEUTICS,2020,587:11. |
| APA | Li, Haiyan.,Zhu, Jie.,Wang, Caifen.,Qin, Wei.,Hu, Xiaoxiao.,...&Zhang, Jiwen.(2020).Paeonol loaded cyclodextrin metal-organic framework particles for treatment of acute lung injury via inhalation.INTERNATIONAL JOURNAL OF PHARMACEUTICS,587,11. |
| MLA | Li, Haiyan,et al."Paeonol loaded cyclodextrin metal-organic framework particles for treatment of acute lung injury via inhalation".INTERNATIONAL JOURNAL OF PHARMACEUTICS 587(2020):11. |
入库方式： OAI收割
来源：上海药物研究所
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