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RUTHENIUM(II)-CATALYZED REGIOSELECTIVE C-H HYDROXYMETHYLATION OF N-ARYL-AZAINDOLES WITH PARAFORMALDEHYDE

文献类型：期刊论文

作者Li, Siqi1,2; Yu, Yang1; Yang, Yaxi2,3; Zhou, Bing2,3
刊名HETEROCYCLES
出版日期2020-06-01
卷号100期号:6页码:934-945
关键词C-H Hydroxymethylation N-Aryl-azaindole
ISSN号0385-5414
DOI10.3987/COM-20-14258
通讯作者Yu, Yang(yangyu2017@shu.edu.cn) ; Zhou, Bing(zhoubing@simm.ac.cn)
英文摘要A facile synthesis of hydroxymethylated N-aryl-azaindoles was developed via a Ru(II)-catalyzed regioselective C-H addition to paraformaldehyde. The reaction is compatible with air, shows high functional group tolerance and regioselectivity, and is an environmentally benign method without any undesired byproduct.
WOS关键词RUTHENIUM-CATALYZED DIRECT ; 7-AZAINDOLES ; FUNCTIONALIZATION ; ALDEHYDES ; ACTIVATION ; ARYLATION ; ALKYLATION ; REACTIVITY ; INDOLINES ; INSERTION
资助项目National Natural Science Foundation of China[21702218] ; National Natural Science Foundation of China[91753207] ; National major science and technology project major new drug creation[2018ZX09711002-006-001] ; National major science and technology project major new drug creation[2018ZX09711002-007] ; Youth Innovation Promotion Association[2017333] ; Shanghai Rising-Star Program[17QA1405000]
WOS研究方向Chemistry
语种英语
WOS记录号WOS:000571526900006
出版者PERGAMON-ELSEVIER SCIENCE LTD
源URL[http://119.78.100.183/handle/2S10ELR8/291216]  
专题新药研究国家重点实验室
通讯作者Yu, Yang; Zhou, Bing
作者单位1.Shanghai Univ, Coll Sci, Dept Chem, 99 Shangda Rd, Shanghai 200444, Peoples R China
2.Chinese Acad Sci, Shanghai Inst Mat Med, Dept Med Chem, State Key Lab Drug Res, 555 Zu Chong Zhi Rd, Shanghai 201203, Peoples R China
3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
推荐引用方式
GB/T 7714		 Li, Siqi,Yu, Yang,Yang, Yaxi,et al. RUTHENIUM(II)-CATALYZED REGIOSELECTIVE C-H HYDROXYMETHYLATION OF N-ARYL-AZAINDOLES WITH PARAFORMALDEHYDE[J]. HETEROCYCLES,2020,100(6):934-945.
APA Li, Siqi,Yu, Yang,Yang, Yaxi,&Zhou, Bing.(2020).RUTHENIUM(II)-CATALYZED REGIOSELECTIVE C-H HYDROXYMETHYLATION OF N-ARYL-AZAINDOLES WITH PARAFORMALDEHYDE.HETEROCYCLES,100(6),934-945.
MLA Li, Siqi,et al."RUTHENIUM(II)-CATALYZED REGIOSELECTIVE C-H HYDROXYMETHYLATION OF N-ARYL-AZAINDOLES WITH PARAFORMALDEHYDE".HETEROCYCLES 100.6(2020):934-945.

入库方式： OAI收割

来源：上海药物研究所

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