Iron-Based Theranostic Nanoplatform for Improving Chemodynamic Therapy of Cancer
文献类型：期刊论文
| 作者 | Liu, Xiao1; Jin, Yilan1,2,3; Liu, Tingting4; Yang, Shengju5; Zhou, Mengxue2,3; Wang, Weiqi1,2,3; Yu, Haijun2,3
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| 刊名 | ACS BIOMATERIALS SCIENCE & ENGINEERING
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| 出版日期 | 2020-09-01 |
| 卷号 | 6期号:9页码:4834-4845 |
| 关键词 | chemodynamic therapy Fenton reaction tumor microenvironment theranostic nanomedicine |
| ISSN号 | 2373-9878 |
| DOI | 10.1021/acsbiomaterials.0c01009 |
| 通讯作者 | Wang, Weiqi(wwq1990@ntu.edu.cn) ; Yu, Haijun(hjyu@simm.ac.cn) |
| 英文摘要 | Chemodynamic therapy (CDT) has aroused extensive attention for cancer treatment in the last five years, as it could suppress tumor progression through in situ detrimental oxidative stress of the tumor cells via the Fenton reaction. Under a tumor acidic microenvironment, the Fenton reaction can be initiated for disproportioning endogenous hydrogen peroxide into highly toxic hydroxyl radical. Taking advantage of the highly tumor-specific therapy modality, various Fenton nanocatalysts have been developed for CDT. In particular, iron-containing Fenton nanocatalysts with minimal cytotoxicity exhibit great promise for clinical translation. In this review, we summarize the recent progress of CDT based on iron-containing nanomaterials, including iron oxide nanoparticles, glassy iron nanoclusters, ferrocene nanoparticles, metal polyphenol networks, metal-organic frameworks, etc. We also discuss the challenges and perspectives for promoting CDT by rational design of iron-containing nanomaterials, highlighting their potential for precise cancer therapy. |
| WOS关键词 | METAL-ORGANIC FRAMEWORKS ; BIODEGRADABLE POLYMERS ; ANTICANCER DRUGS ; ROS GENERATION ; IN-SITU ; NANOPARTICLES ; TUMOR ; NANOCATALYSTS ; HYPERTHERMIA ; EFFICIENCY |
| 资助项目 | National Natural Science Foundation of China[31900990] ; National Natural Science Foundation of China[51873228] ; National Natural Science Foundation of China[31671024] ; Natural Science Foundation of Nantong in China[JC2018153] |
| WOS研究方向 | Materials Science |
| 语种 | 英语 |
| WOS记录号 | WOS:000572822300006 |
| 出版者 | AMER CHEMICAL SOC |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/291270]  |
| 专题 | 新药研究国家重点实验室 |
| 通讯作者 | Wang, Weiqi; Yu, Haijun |
| 作者单位 | 1.Nantong Univ, Sch Pharm, Nantong 226001, Jiangsu, Peoples R China 2.Chinese Acad Sci, State Key Lab Drug Res, Shanghai 201203, Peoples R China 3.Chinese Acad Sci, Ctr Pharmaceut, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China 4.Nantong Univ, Dept Med Imaging, Affiliated Hosp, Nantong, Jiangsu, Peoples R China 5.Nantong Univ, Affiliated Hosp, Dept Dermatol, Nantong 226001, Jiangsu, Peoples R China |
| 推荐引用方式 GB/T 7714 | Liu, Xiao,Jin, Yilan,Liu, Tingting,et al. Iron-Based Theranostic Nanoplatform for Improving Chemodynamic Therapy of Cancer[J]. ACS BIOMATERIALS SCIENCE & ENGINEERING,2020,6(9):4834-4845. |
| APA | Liu, Xiao.,Jin, Yilan.,Liu, Tingting.,Yang, Shengju.,Zhou, Mengxue.,...&Yu, Haijun.(2020).Iron-Based Theranostic Nanoplatform for Improving Chemodynamic Therapy of Cancer.ACS BIOMATERIALS SCIENCE & ENGINEERING,6(9),4834-4845. |
| MLA | Liu, Xiao,et al."Iron-Based Theranostic Nanoplatform for Improving Chemodynamic Therapy of Cancer".ACS BIOMATERIALS SCIENCE & ENGINEERING 6.9(2020):4834-4845. |
入库方式： OAI收割
来源：上海药物研究所
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