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Supramolecular Assembly of TPE-Based Glycoclusters with Dicyanomethylene-4H-pyran (DM) Fluorescent Probes Improve Their Properties for Peroxynitrite Sensing and Cell Imaging

文献类型：期刊论文

作者Dong, Lei1,2,3; Fu, Mengqi1,2; Liu, Lifang1,2; Han, Hai-Hao1,2; Zang, Yi4; Chen, Guo-Rong1,2; Li, Jia4; He, Xiao-Peng1,2; Vidal, Sebastien3
刊名CHEMISTRY-A EUROPEAN JOURNAL
出版日期2020-10-06
页码9
关键词cell imaging glycoclusters peroxynitrite detection self-assembly tetraphenylethylene
ISSN号0947-6539
DOI10.1002/chem.202002772
通讯作者Li, Jia(jli@simm.ac.cn) ; He, Xiao-Peng(xphe@ecust.edu.cn) ; Vidal, Sebastien(sebastien.vidal@univ-lyon1.fr)
英文摘要Two red-emitting dicyanomethylene-4H-pyran (DM) based fluorescent probes were designed and used for peroxynitrite (ONOO-) detection. Nevertheless, the aggregation-caused quenching effect diminished the fluorescence and restricted their further applications. To overcome this problem, tetraphenylethylene (TPE) based glycoclusters were used to self-assemble with these DM probes to obtain supramolecular water-soluble glyco-dots. This self-assembly strategy enhanced the fluorescence intensity, leading to an enhanced selectivity and activity of the resulting glyco-dot comparing to DM probes alone in PBS buffer. The glyco-dots also exhibited better results during fluorescence sensing of intracellular ONOO(-)than the probes alone, thereby offering scope for the development of other similar supramolecular glyco-systems for chemical biological studies.
WOS关键词PERYLENEDIIMIDE-BASED GLYCOCLUSTERS ; SELECTIVE DETECTION ; GALACTOSIDASE ; TRACKING ; RECEPTOR
资助项目Universite Claude Bernard Lyon 1 ; CNRS ; Natural Science Foundation of China[21788102] ; Natural Science Foundation of China[91853201] ; Natural Science Foundation of China[21722801] ; Natural Science Foundation of China[21776078] ; Shanghai Municipal Science and Technology Major Project[2018SHZDZX03] ; National Key Sci-Tech Special Projects of Infection Diseases of China[2018ZX10732202] ; international cooperation program of Shanghai Science and Technology Committee[17520750100] ; China Scholarship Council[201606740066]
WOS研究方向Chemistry
语种英语
WOS记录号WOS:000575265700001
出版者WILEY-V C H VERLAG GMBH
源URL[http://119.78.100.183/handle/2S10ELR8/291309]  
专题新药研究国家重点实验室
通讯作者Li, Jia; He, Xiao-Peng; Vidal, Sebastien
作者单位1.East China Univ Sci & Technol, Key Lab Adv Mat, Feringa Nobel Prize Scientist Joint Res Ctr, Sch Chem & Mol Engn,Frontiers Ctr Mat & Dynam Che, 130 Meilong Rd, Shanghai 200237, Peoples R China
2.East China Univ Sci & Technol, Joint Int Res Lab Precis Chem & Mol Engn, Feringa Nobel Prize Scientist Joint Res Ctr, Sch Chem & Mol Engn,Frontiers Ctr Mat & Dynam Che, 130 Meilong Rd, Shanghai 200237, Peoples R China
3.Univ Lyon, Inst Chim & Biochim Mol & Supramol, Lab Chim Organ 2 Glycochim, UMR 5246,CNRS,Univ Claude Bernard Lyon 1, 1 Rue Victor Grignard, F-69622 Villeurbanne, France
4.Chinese Acad Sci, Natl Ctr Drug Screening, State Key Lab Drug Res, Shanghai Inst Mat Med, 189 Guo Shoujing Rd, Shanghai 201203, Peoples R China
推荐引用方式
GB/T 7714		 Dong, Lei,Fu, Mengqi,Liu, Lifang,et al. Supramolecular Assembly of TPE-Based Glycoclusters with Dicyanomethylene-4H-pyran (DM) Fluorescent Probes Improve Their Properties for Peroxynitrite Sensing and Cell Imaging[J]. CHEMISTRY-A EUROPEAN JOURNAL,2020:9.
APA Dong, Lei.,Fu, Mengqi.,Liu, Lifang.,Han, Hai-Hao.,Zang, Yi.,...&Vidal, Sebastien.(2020).Supramolecular Assembly of TPE-Based Glycoclusters with Dicyanomethylene-4H-pyran (DM) Fluorescent Probes Improve Their Properties for Peroxynitrite Sensing and Cell Imaging.CHEMISTRY-A EUROPEAN JOURNAL,9.
MLA Dong, Lei,et al."Supramolecular Assembly of TPE-Based Glycoclusters with Dicyanomethylene-4H-pyran (DM) Fluorescent Probes Improve Their Properties for Peroxynitrite Sensing and Cell Imaging".CHEMISTRY-A EUROPEAN JOURNAL (2020):9.

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来源：上海药物研究所

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