中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
首页 机构 成果 学者
  
  1. CAS IR Grid
  2. 上海药物研究所
  3. 中国科学院上海药物研究所
  4. 新药研究国家重点实验室
Rare new bicyclic cembranoid ethers and a novel trihydroxy prenylated guaiane from the Xisha soft coral Lobophytum sp

文献类型：期刊论文

作者Li, Song-Wei1,2; Cuadrado, Cristina3; Huan, Xia-Juan2; Yao, Li-Gong2; Miao, Ze-Hong2; Hernandez Daranas, Antonio3; Guo, Yue-Wei1,2
刊名BIOORGANIC CHEMISTRY
出版日期2020-10-01
卷号103页码:12
关键词Soft coral Lobophytum Cembranoids Marine natural products Quantum mechanical calculations
ISSN号0045-2068
DOI10.1016/j.bioorg.2020.104223
通讯作者Miao, Ze-Hong(zhmiao@simm.ac.cn) ; Hernandez Daranas, Antonio(adaranas@ipna.csic.es) ; Guo, Yue-Wei(ywguo@simm.ac.cn)
英文摘要Seven new cembrane-type diterpenes, lobophytolins C-I (3-9), and one new prenylated-guiane-type diterpene, lobophytolin J (10), along with six known related ones (1, 2, 11-14), have been isolated from the soft coral Lobophytum sp. collected off the Xisha Island in the South China Sea. Their structures were elucidated by extensive spectroscopic analysis and quantum mechanical (QM)-NMR methods. The absolute configuration of lobophytolin H (8) was determined by the application of the modified Mosher's method and chemical transformation. Lobophytolin D (4) exhibited promising cytotoxicities in in vitro bioassays against HT-29, Capan-1, A549, and SNU-398 human cancer cell lines with IC50, values of 4.52, 6.62, 5.17, and 6.15 mu M, respectively.
WOS关键词C-13 CHEMICAL-SHIFTS ; COMPUTATIONAL CHEMISTRY ; NMR-SPECTROSCOPY ; CONFIGURATION ; DITERPENOIDS ; PROTON ; DP4
资助项目Natural Science Foundation of China[81991521] ; Natural Science Foundation of China[81520108028] ; Natural Science Foundation of China[21672230] ; National Key Research and Development Program of China[2018YFC0310903] ; Drug Innovation Major Project[2018ZX09711-001-001-009] ; SKLDR/SIMM Project[SIMM1903ZZ-04] ; Spanish Ministry of Science and Innovation[PID2019-109476RB-C21] ; CSIC
WOS研究方向Biochemistry & Molecular Biology ; Chemistry
语种英语
WOS记录号WOS:000575792900009
出版者ACADEMIC PRESS INC ELSEVIER SCIENCE
源URL[http://119.78.100.183/handle/2S10ELR8/291322]  
专题新药研究国家重点实验室
通讯作者Miao, Ze-Hong; Hernandez Daranas, Antonio; Guo, Yue-Wei
作者单位1.Nanjing Univ Chinese Med, Sch Chinese Mat Med, 138 Xianlin Rd, Nanjing 210023, Peoples R China
2.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, 555 Zu Chong Zhi Rd,Zhangjiang Hitech Pk, Shanghai 201203, Peoples R China
3.Consejo Super Invest Cient IPNA CSIC, Inst Prod Nat & Agrobiol, Tenerife 38206, Spain
推荐引用方式
GB/T 7714		 Li, Song-Wei,Cuadrado, Cristina,Huan, Xia-Juan,et al. Rare new bicyclic cembranoid ethers and a novel trihydroxy prenylated guaiane from the Xisha soft coral Lobophytum sp[J]. BIOORGANIC CHEMISTRY,2020,103:12.
APA Li, Song-Wei.,Cuadrado, Cristina.,Huan, Xia-Juan.,Yao, Li-Gong.,Miao, Ze-Hong.,...&Guo, Yue-Wei.(2020).Rare new bicyclic cembranoid ethers and a novel trihydroxy prenylated guaiane from the Xisha soft coral Lobophytum sp.BIOORGANIC CHEMISTRY,103,12.
MLA Li, Song-Wei,et al."Rare new bicyclic cembranoid ethers and a novel trihydroxy prenylated guaiane from the Xisha soft coral Lobophytum sp".BIOORGANIC CHEMISTRY 103(2020):12.

入库方式： OAI收割

来源：上海药物研究所

浏览0
下载0
收藏0
其他版本

除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。