Biodistribution and immunomodulatory activities of a proteoglycan isolated from Ganoderma lucidum
文献类型：期刊论文
| 作者 | Teng, Yilong1; Liang, Haohui1; Zhang, Zeng2; He, Yanming2; Pan, Yanna1; Yuan, Shilin1; Wu, Xiao1; Zhao, Qingjie3 ; Yang, Hongjie2; Zhou, Ping1
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| 刊名 | JOURNAL OF FUNCTIONAL FOODS
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| 出版日期 | 2020-11-01 |
| 卷号 | 74页码:13 |
| ISSN号 | 1756-4646 |
| 关键词 | Proteoglycan Ganoderma lucidum Bioavailability Macrophage Immunoregulation |
| DOI | 10.1016/j.jff.2020.104193 |
| 通讯作者 | Zhao, Qingjie(zhaoqingjie@simm.ac.cn) ; Yang, Hongjie(yanghongjie1964@aliyun.com) ; Zhou, Ping(pingzhou@fudan.edu.cn) |
| 英文摘要 | A proteoglycan, namely FYGL extracted from Ganoderma lucidum, was proved previously efficient for anti-diabetes in vivo. However, many medicine functions of FYGL have not been revealed, such as immunoregulation, an important function of Ganoderma in the traditional Chinese medicine. In this work, we firstly investigated the distribution of FYGL orally administrated by mice and found that FYGL was available in small intestine and viscera organs and enriched mostly in liver. Consequently, we studied the immunoregulation mechanism of FYGL in RAW 264.7 macrophages. The results showed that FYGL could induce initially ROS and trigger Ca2+ ions influx into cells, leading to the activation of NF-KB and MAPK signaling to secret NO and cytokines for immune responses, and the promotion of phagocytosis. Meanwhile, FYGL absorbed in cells could reduce ROS, therefore preventing mitochondrial membrane from damage for cells safety. The results provided the immunoregulation basis of FYGL potentially applicable in clinics. |
| WOS关键词 | NF-KAPPA-B ; INNATE IMMUNE-RESPONSE ; STRUCTURAL-CHARACTERIZATION ; FRUITING BODIES ; POLYSACCHARIDES ; MACROPHAGE ; ENDOCYTOSIS ; PURIFICATION ; ACTIVATION ; INHIBITOR |
| 资助项目 | National Natural Science Foundation of China[21374022] ; National Natural Science Foundation of China[81374032] ; National Health Commission of the People's Republic of China[2017ZX09301006] ; Science and Technology Commission of Shanghai Municipality[17401902700] |
| WOS研究方向 | Food Science & Technology ; Nutrition & Dietetics |
| 语种 | 英语 |
| 出版者 | ELSEVIER |
| WOS记录号 | WOS:000576946500002 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/291344]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Zhao, Qingjie; Yang, Hongjie; Zhou, Ping |
| 作者单位 | 1.Fudan Univ, Dept Macromol Sci, State Key Lab Mol Engn Polymers, Shanghai 200433, Peoples R China 2.Shanghai Univ Tradit Chinese Med, Yueyang Hosp Integrated Tradit Chinese & Western, Shanghai 200437, Peoples R China 3.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Teng, Yilong,Liang, Haohui,Zhang, Zeng,et al. Biodistribution and immunomodulatory activities of a proteoglycan isolated from Ganoderma lucidum[J]. JOURNAL OF FUNCTIONAL FOODS,2020,74:13. |
| APA | Teng, Yilong.,Liang, Haohui.,Zhang, Zeng.,He, Yanming.,Pan, Yanna.,...&Zhou, Ping.(2020).Biodistribution and immunomodulatory activities of a proteoglycan isolated from Ganoderma lucidum.JOURNAL OF FUNCTIONAL FOODS,74,13. |
| MLA | Teng, Yilong,et al."Biodistribution and immunomodulatory activities of a proteoglycan isolated from Ganoderma lucidum".JOURNAL OF FUNCTIONAL FOODS 74(2020):13. |
入库方式： OAI收割
来源：上海药物研究所
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