中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
Chemical Constituents from Citrus changshan-huyou and Their Anti-Inflammatory Activities

文献类型:期刊论文

作者Hu, Yu-Hong1,2; Liu, Jin2; Li, Heng2; Tang, Wei2; Li, Xu-Wen2; Guo, Yue-Wei2
刊名CHEMISTRY & BIODIVERSITY
出版日期2020-10-16
页码10
关键词Citrus changshan-huyou limonoids structure modification anti-inflammation
ISSN号1612-1872
DOI10.1002/cbdv.202000503
通讯作者Li, Xu-Wen(xwli@simm.ac.cn) ; Guo, Yue-Wei(ywguo@simm.ac.cn)
英文摘要A systematically chemical investigation ofCitrus changshan-huyouY.B.Chang resulted in the isolation and structure determination of twelve known natural products, including limonoid, nootkatone, scoparone, beta-sitosterol, 3,3 ',4 ',5,6,7,8,-heptamethoxyflavone, nobiletin, tangeretin, naringin, hesperidin, neohesperidin, 3,5-dihydroxyphenyl beta-D-glucoside, beta-sitosterol-D-glucoside. The structure modification of the most abundant compound limonin further led to eight limonoid derivatives, including epi-limonol, epi-limonyl acetate, and six new compoundsepi-limonol A, limonol A, limonol B, epi-limonol B, epi-limonol C, epi-limonol D, which enlarged the chemical diversity of limonin related limonoids. The structures of the new limonoid derivatives were identified by extensive spectroscopic analysis. In bioassay, all the isolates, the semi-synthetic derivatives and the previously isolated limonoids in our natural product library were subjected for anti-inflammatory activities evaluation, and several limonoids exhibited the inhibition of TNF-alpha release.
WOS关键词DERIVATIVES ; AGENTS ; IDENTIFICATION ; LIMONOIDS ; PEELS ; NMR
资助项目Drug Innovation Major Project[2018ZX09711-001-001-009]
WOS研究方向Biochemistry & Molecular Biology ; Chemistry
语种英语
WOS记录号WOS:000577602800001
出版者WILEY-V C H VERLAG GMBH
源URL[http://119.78.100.183/handle/2S10ELR8/291347]  
专题新药研究国家重点实验室
通讯作者Li, Xu-Wen; Guo, Yue-Wei
作者单位1.Zhanhong Biotechnol Co Ltd, Changshan Eco Ind Pk, Quzhou 324202, Zhejiang, Peoples R China
2.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, 555 Zu Chong Zhi Rd,Zhangjiang Hitech Pk, Shanghai 201203, Peoples R China
推荐引用方式
GB/T 7714
Hu, Yu-Hong,Liu, Jin,Li, Heng,et al. Chemical Constituents from Citrus changshan-huyou and Their Anti-Inflammatory Activities[J]. CHEMISTRY & BIODIVERSITY,2020:10.
APA Hu, Yu-Hong,Liu, Jin,Li, Heng,Tang, Wei,Li, Xu-Wen,&Guo, Yue-Wei.(2020).Chemical Constituents from Citrus changshan-huyou and Their Anti-Inflammatory Activities.CHEMISTRY & BIODIVERSITY,10.
MLA Hu, Yu-Hong,et al."Chemical Constituents from Citrus changshan-huyou and Their Anti-Inflammatory Activities".CHEMISTRY & BIODIVERSITY (2020):10.

入库方式: OAI收割

来源:上海药物研究所

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