Chemical Constituents from Citrus changshan-huyou and Their Anti-Inflammatory Activities
文献类型:期刊论文
作者 | Hu, Yu-Hong1,2; Liu, Jin2; Li, Heng2; Tang, Wei2![]() ![]() ![]() |
刊名 | CHEMISTRY & BIODIVERSITY
![]() |
出版日期 | 2020-10-16 |
页码 | 10 |
关键词 | Citrus changshan-huyou limonoids structure modification anti-inflammation |
ISSN号 | 1612-1872 |
DOI | 10.1002/cbdv.202000503 |
通讯作者 | Li, Xu-Wen(xwli@simm.ac.cn) ; Guo, Yue-Wei(ywguo@simm.ac.cn) |
英文摘要 | A systematically chemical investigation ofCitrus changshan-huyouY.B.Chang resulted in the isolation and structure determination of twelve known natural products, including limonoid, nootkatone, scoparone, beta-sitosterol, 3,3 ',4 ',5,6,7,8,-heptamethoxyflavone, nobiletin, tangeretin, naringin, hesperidin, neohesperidin, 3,5-dihydroxyphenyl beta-D-glucoside, beta-sitosterol-D-glucoside. The structure modification of the most abundant compound limonin further led to eight limonoid derivatives, including epi-limonol, epi-limonyl acetate, and six new compoundsepi-limonol A, limonol A, limonol B, epi-limonol B, epi-limonol C, epi-limonol D, which enlarged the chemical diversity of limonin related limonoids. The structures of the new limonoid derivatives were identified by extensive spectroscopic analysis. In bioassay, all the isolates, the semi-synthetic derivatives and the previously isolated limonoids in our natural product library were subjected for anti-inflammatory activities evaluation, and several limonoids exhibited the inhibition of TNF-alpha release. |
WOS关键词 | DERIVATIVES ; AGENTS ; IDENTIFICATION ; LIMONOIDS ; PEELS ; NMR |
资助项目 | Drug Innovation Major Project[2018ZX09711-001-001-009] |
WOS研究方向 | Biochemistry & Molecular Biology ; Chemistry |
语种 | 英语 |
WOS记录号 | WOS:000577602800001 |
出版者 | WILEY-V C H VERLAG GMBH |
源URL | [http://119.78.100.183/handle/2S10ELR8/291347] ![]() |
专题 | 新药研究国家重点实验室 |
通讯作者 | Li, Xu-Wen; Guo, Yue-Wei |
作者单位 | 1.Zhanhong Biotechnol Co Ltd, Changshan Eco Ind Pk, Quzhou 324202, Zhejiang, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, 555 Zu Chong Zhi Rd,Zhangjiang Hitech Pk, Shanghai 201203, Peoples R China |
推荐引用方式 GB/T 7714 | Hu, Yu-Hong,Liu, Jin,Li, Heng,et al. Chemical Constituents from Citrus changshan-huyou and Their Anti-Inflammatory Activities[J]. CHEMISTRY & BIODIVERSITY,2020:10. |
APA | Hu, Yu-Hong,Liu, Jin,Li, Heng,Tang, Wei,Li, Xu-Wen,&Guo, Yue-Wei.(2020).Chemical Constituents from Citrus changshan-huyou and Their Anti-Inflammatory Activities.CHEMISTRY & BIODIVERSITY,10. |
MLA | Hu, Yu-Hong,et al."Chemical Constituents from Citrus changshan-huyou and Their Anti-Inflammatory Activities".CHEMISTRY & BIODIVERSITY (2020):10. |
入库方式: OAI收割
来源:上海药物研究所
浏览0
下载0
收藏0
其他版本
除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。