中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
Anti-inflammatory signaling through G protein-coupled receptors

文献类型:期刊论文

作者Ge, Yun-jun1,2; Liao, Qi-wen2; Xu, Ye-chun3,4; Zhao, Qiang4,5; Wu, Bei-li3,4; Ye, Richard D.1,2
刊名ACTA PHARMACOLOGICA SINICA
出版日期2020-10-15
页码8
ISSN号1671-4083
DOI10.1038/s41401-020-00523-1
通讯作者Ye, Richard D.(richardye@cuhk.edu.cn)
英文摘要G protein-coupled receptors (GPCRs) play important roles in human physiology. GPCRs are involved in immunoregulation including regulation of the inflammatory response. Chemotaxis of phagocytes and lymphocytes is mediated to a great extent by the GPCRs for chemoattractants including myriads of chemokines. Accumulation and activation of phagocytes at the site of inflammation contribute to local inflammatory response. A handful of GPCRs have been found to transduce anti-inflammatory signals that promote resolution of inflammation. These GPCRs interact with selected metabolites of arachdonic acid, such as lipoxins, and of omega-3 essential fatty acids, such as resolvins and protectins. Despite mounting evidence for the in vivo functions of these anti-inflammatory and pro-resolving ligands paired with their respective GPCRs, the underlying signaling mechanisms have not been fully delineated. The present review summarizes what we have learned about these GPCRs, their structures and signaling pathways and the prospect of targeting these receptors for novel anti-inflammatory therapies.
WOS关键词FORMYL PEPTIDE RECEPTOR ; PRO-RESOLVING MEDIATORS ; LIPOXIN A(4) ; LIGAND-BINDING ; IDENTIFICATION ; ACTIVATION ; RESOLUTION ; FPR2/ALX ; ANALOGS ; CELLS
资助项目Fundo para o Desenvolvimento das Ciencias e da Tecnologia[FDCT 072/2015/A2] ; University of Macau[MYRG2016-00246-ICMS-QRCM] ; Chinese University of Hong Kong, Shenzhen ; Ganghong Young Scholar Development Fund
WOS研究方向Chemistry ; Pharmacology & Pharmacy
语种英语
WOS记录号WOS:000577860600001
出版者NATURE PUBLISHING GROUP
源URL[http://119.78.100.183/handle/2S10ELR8/291363]  
专题新药研究国家重点实验室
通讯作者Ye, Richard D.
作者单位1.Univ Macau, Inst Chinese Med Sci, Macau Sar, Peoples R China
2.Chinese Univ Hong Kong, Sch Life & Hlth Sci, Shenzhen 518172, Peoples R China
3.Chinese Acad Sci, Shanghai Inst Mat Med, CAS Key Lab Receptor Res, Shanghai 201203, Peoples R China
4.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
5.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China
推荐引用方式
GB/T 7714
Ge, Yun-jun,Liao, Qi-wen,Xu, Ye-chun,et al. Anti-inflammatory signaling through G protein-coupled receptors[J]. ACTA PHARMACOLOGICA SINICA,2020:8.
APA Ge, Yun-jun,Liao, Qi-wen,Xu, Ye-chun,Zhao, Qiang,Wu, Bei-li,&Ye, Richard D..(2020).Anti-inflammatory signaling through G protein-coupled receptors.ACTA PHARMACOLOGICA SINICA,8.
MLA Ge, Yun-jun,et al."Anti-inflammatory signaling through G protein-coupled receptors".ACTA PHARMACOLOGICA SINICA (2020):8.

入库方式: OAI收割

来源:上海药物研究所

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