Anti-inflammatory signaling through G protein-coupled receptors
文献类型：期刊论文
| 作者 | Ge, Yun-jun1,2; Liao, Qi-wen2; Xu, Ye-chun3,4 ; Zhao, Qiang4,5; Wu, Bei-li3,4; Ye, Richard D.1,2
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| 刊名 | ACTA PHARMACOLOGICA SINICA
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| 出版日期 | 2020-10-15 |
| 页码 | 8 |
| ISSN号 | 1671-4083 |
| DOI | 10.1038/s41401-020-00523-1 |
| 通讯作者 | Ye, Richard D.(richardye@cuhk.edu.cn) |
| 英文摘要 | G protein-coupled receptors (GPCRs) play important roles in human physiology. GPCRs are involved in immunoregulation including regulation of the inflammatory response. Chemotaxis of phagocytes and lymphocytes is mediated to a great extent by the GPCRs for chemoattractants including myriads of chemokines. Accumulation and activation of phagocytes at the site of inflammation contribute to local inflammatory response. A handful of GPCRs have been found to transduce anti-inflammatory signals that promote resolution of inflammation. These GPCRs interact with selected metabolites of arachdonic acid, such as lipoxins, and of omega-3 essential fatty acids, such as resolvins and protectins. Despite mounting evidence for the in vivo functions of these anti-inflammatory and pro-resolving ligands paired with their respective GPCRs, the underlying signaling mechanisms have not been fully delineated. The present review summarizes what we have learned about these GPCRs, their structures and signaling pathways and the prospect of targeting these receptors for novel anti-inflammatory therapies. |
| WOS关键词 | FORMYL PEPTIDE RECEPTOR ; PRO-RESOLVING MEDIATORS ; LIPOXIN A(4) ; LIGAND-BINDING ; IDENTIFICATION ; ACTIVATION ; RESOLUTION ; FPR2/ALX ; ANALOGS ; CELLS |
| 资助项目 | Fundo para o Desenvolvimento das Ciencias e da Tecnologia[FDCT 072/2015/A2] ; University of Macau[MYRG2016-00246-ICMS-QRCM] ; Chinese University of Hong Kong, Shenzhen ; Ganghong Young Scholar Development Fund |
| WOS研究方向 | Chemistry ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000577860600001 |
| 出版者 | NATURE PUBLISHING GROUP |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/291363]  |
| 专题 | 新药研究国家重点实验室 |
| 通讯作者 | Ye, Richard D. |
| 作者单位 | 1.Univ Macau, Inst Chinese Med Sci, Macau Sar, Peoples R China 2.Chinese Univ Hong Kong, Sch Life & Hlth Sci, Shenzhen 518172, Peoples R China 3.Chinese Acad Sci, Shanghai Inst Mat Med, CAS Key Lab Receptor Res, Shanghai 201203, Peoples R China 4.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 5.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Ge, Yun-jun,Liao, Qi-wen,Xu, Ye-chun,et al. Anti-inflammatory signaling through G protein-coupled receptors[J]. ACTA PHARMACOLOGICA SINICA,2020:8. |
| APA | Ge, Yun-jun,Liao, Qi-wen,Xu, Ye-chun,Zhao, Qiang,Wu, Bei-li,&Ye, Richard D..(2020).Anti-inflammatory signaling through G protein-coupled receptors.ACTA PHARMACOLOGICA SINICA,8. |
| MLA | Ge, Yun-jun,et al."Anti-inflammatory signaling through G protein-coupled receptors".ACTA PHARMACOLOGICA SINICA (2020):8. |
入库方式： OAI收割
来源：上海药物研究所
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