中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
首页 机构 成果 学者
  
  1. CAS IR Grid
  2. 上海药物研究所
  3. 中国科学院上海药物研究所
Nostoc sphaeroids Kutz polysaccharide and powder enrich a core bacterial community on C57BL/6j mice

文献类型：期刊论文

作者Li, Meixia1,2; Guo, Ciliang1,2; Wang, Yeqing1,2; Du, Zhenyun1,2; Chen, Sheng3; Wang, Yulan3; Ding, Kan1,2
刊名INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
出版日期2020-11-01
卷号162页码:1734-1742
ISSN号0141-8130
关键词Nostoc sphaeroids Kutz polysaccharide Nostoc sphaeroids Kutz powder 16S ribosomal RNA gene sequencing Core bacterial community
DOI10.1016/j.ijbiomac.2020.08.026
通讯作者Ding, Kan(dingkan@simm.ac.cn)
英文摘要Gut microbiota is the collection of microbes that lives in the host. Glycan is the major factor to shape the composition of microbial community. Nostoc sphaeroids Kutz (NSK) has been used as food and medicine for thousands of years in Asian countries while the bioactivity on gut microbiota is unclear till now. Here, we used NSK polysaccharide and NSK powder to investigate the bioactivity on the gut microbiota of C57BL/6j mice, respectively. By 16S ribosomal RNA gene sequencing, we found the composition of gut microbiota had been changed and differed from each other. However, the abundance of Bacteroides, Parabacteroides, Escherichia-Shigella and Parasutterella on genus level were significantly increased by NSK polysaccharide and NSK powder. In addition, Akkermansia and Rikenellaceae were enriched by NSK powder. Moreover, we found the IL-1 beta and IL-6 decreased significantly while TNF-alpha and IL-10 increased significantly especially in NSK powder group. Intriguingly, the increased microbes were significantly positively co-related with TNF-alpha and IL-10 while negatively co-related with IL-1 beta and IL-6 by co-relation and network analysis. The above results suggested that Nostoc sphaeroids Kutz may selectively enrich a "core bacterial community" and add new evidence to discover how Nostoc sphaeroids Kutz has biological function. (C) 2020 Published by Elsevier B.V.
WOS关键词CHAIN FATTY-ACIDS ; GUT MICROBIOTA ; DIETARY FIBER ; METABOLISM ; MODULATION ; PHYSIOLOGY ; DIVERSITY ; OBESITY
资助项目Hunan Yandi Bioengineering Co. Ltd. Zhuzhou, Hunan Province, China ; National Key New Drug Creation and Manufacturing Program, Ministry of Science and Technology[2019ZX09735001]
WOS研究方向Biochemistry & Molecular Biology ; Chemistry ; Polymer Science
语种英语
出版者ELSEVIER
WOS记录号WOS:000577953700064
源URL[http://119.78.100.183/handle/2S10ELR8/291411]  
专题中国科学院上海药物研究所
通讯作者Ding, Kan
作者单位1.Chinese Acad Sci, Key Lab Receptor Res, Shanghai Inst Mat Med, Glycochem & Glycobiol Lab, 555 Zu Chong Zhi Rd, Beijing 100049, Peoples R China
2.Univ Chinese Acad Sci, 19A Yuquan Rd, Beijing 100049, Peoples R China
3.Hunan Yandi Bioengn Co Ltd, Zhuzhou 412000, Hunan, Peoples R China
推荐引用方式
GB/T 7714		 Li, Meixia,Guo, Ciliang,Wang, Yeqing,et al. Nostoc sphaeroids Kutz polysaccharide and powder enrich a core bacterial community on C57BL/6j mice[J]. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,2020,162:1734-1742.
APA Li, Meixia.,Guo, Ciliang.,Wang, Yeqing.,Du, Zhenyun.,Chen, Sheng.,...&Ding, Kan.(2020).Nostoc sphaeroids Kutz polysaccharide and powder enrich a core bacterial community on C57BL/6j mice.INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,162,1734-1742.
MLA Li, Meixia,et al."Nostoc sphaeroids Kutz polysaccharide and powder enrich a core bacterial community on C57BL/6j mice".INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES 162(2020):1734-1742.

入库方式： OAI收割

来源：上海药物研究所

浏览0
下载0
收藏0
其他版本

除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。