A removable directing group-assisted Rh(iii)-catalyzed direct C-H bond activation/annulation cascade to synthesize highly fused isoquinolines
文献类型：期刊论文
| 作者 | Cheng, Yilang1,2,3,4; Han, Xu1,2,3; Li, Junyou1,2,3; Zhou, Yu1,2,3 ; Liu, Hong1,2,3,4
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| 刊名 | ORGANIC CHEMISTRY FRONTIERS
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| 出版日期 | 2020-10-21 |
| 卷号 | 7期号:20页码:3186-3192 |
| ISSN号 | 2052-4129 |
| DOI | 10.1039/d0qo00786b |
| 通讯作者 | Zhou, Yu() ; Liu, Hong() |
| 英文摘要 | An azomethine imine-directed Rh(iii)-catalyzed C-H functionalization/annulation cascade to construct highly fused isoquinoline scaffolds, in which the azomethine imine was used as a removable directing group and could be removedin situunder mild reaction conditions with good to excellent yields, accompanied by a broad substrate scope and good functional group tolerance was developed. Notably, this strategy could be further extended to late-stage modification of drug molecules, offering more potential in drug discoveries. |
| WOS关键词 | RHODIUM(III)-CATALYZED SYNTHESIS ; SULFOXONIUM YLIDES ; ACTIVATION ; ANNULATION ; AMIDATION ; ACCESS ; FUNCTIONALIZATION ; AZOBENZENES ; IMIDAMIDES ; CLEAVAGE |
| 资助项目 | National Natural Science Foundation of China[21672232] ; National Natural Science Foundation of China[21977106] ; National Natural Science Foundation of China[21632008] ; National S&T Major Projects[2018ZX09711002] ; Strategic Priority Research Program of the Chinese Academy of Sciences[XDA12040217] ; Shanghai Science and Technology Development Funds[19431901000] |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000579143200006 |
| 出版者 | ROYAL SOC CHEMISTRY |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/291446]  |
| 专题 | 新药研究国家重点实验室 |
| 通讯作者 | Zhou, Yu; Liu, Hong |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, 555 Zu Chong Zhi Rd, Shanghai 201203, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Mat Med, CAS Key Lab Receptor Res, 555 Zu Chong Zhi Rd, Shanghai 201203, Peoples R China 3.Univ Chinese Acad Sci, 19A Yuquan Rd, Beijing 100049, Peoples R China 4.ShanghaiTech Univ, Sch Life Sci & Technol, 100 Haike Rd, Shanghai 201210, Peoples R China |
| 推荐引用方式 GB/T 7714 | Cheng, Yilang,Han, Xu,Li, Junyou,et al. A removable directing group-assisted Rh(iii)-catalyzed direct C-H bond activation/annulation cascade to synthesize highly fused isoquinolines[J]. ORGANIC CHEMISTRY FRONTIERS,2020,7(20):3186-3192. |
| APA | Cheng, Yilang,Han, Xu,Li, Junyou,Zhou, Yu,&Liu, Hong.(2020).A removable directing group-assisted Rh(iii)-catalyzed direct C-H bond activation/annulation cascade to synthesize highly fused isoquinolines.ORGANIC CHEMISTRY FRONTIERS,7(20),3186-3192. |
| MLA | Cheng, Yilang,et al."A removable directing group-assisted Rh(iii)-catalyzed direct C-H bond activation/annulation cascade to synthesize highly fused isoquinolines".ORGANIC CHEMISTRY FRONTIERS 7.20(2020):3186-3192. |
入库方式： OAI收割
来源：上海药物研究所
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