Glycoside scutellarin enhanced CD-MOF anchoring for laryngeal delivery
文献类型：期刊论文
| 作者 | Zhao, Kena1,2; Guo, Tao2; Wang, Caifen2; Zhou, Yong2,4; Xiong, Ting2,4; Wu, Li2; Li, Xue6; Mittal, Priyanka2,5; Shi, Senlin1; Gref, Ruxandra6 |
| 刊名 | ACTA PHARMACEUTICA SINICA B
 |
| 出版日期 | 2020-09-01 |
| 卷号 | 10期号:9页码:1709-1718 |
| 关键词 | Laryngeal delivery gamma-Cyclodextrin metal-organic framework Scutellarin Dexamethasone Molecular simulation |
| ISSN号 | 2211-3835 |
| DOI | 10.1016/j.apsb.2020.04.015 |
| 通讯作者 | Shi, Senlin(pjstone@163.com) ; Gref, Ruxandra(ruxandra.gref@universite-paris-saclay.fr) ; Zhang, Jiwen(jwzhang@simm.ac.cn) |
| 英文摘要 | It is essential to develop new carriers for laryngeal drug delivery in light of the lack of therapy in laryngeal related diseases. When the inhalable micron-sized crystals of gamma-cyclodextrin metal-organic framework (CD-MOF) was utilized as dry powder inhalers (DPIs) carrier with high fine particle fraction (FPF), it was found in this research that the encapsulation of a glycoside compound, namely, scutellarin (SCU) in CD-MOF could significantly enhance its laryngeal deposition. Firstly, SCU loading into CD-MOF was optimized by incubation. Then, a series of characterizations were carried out to elucidate the mechanisms of drug loading. Finally, the laryngeal deposition rate of CD-MOF was 57.72 +/- 12.19% improved by SCU, about two times higher than that of CD-MOF, when it was determined by Next Generation Impactor (NGI) at 65 L/min. As a proof of concept, pharyngolaryngitis therapeutic agent dexamethasone (DEX) had improved laryngeal deposition after being co-encapsulated with SCU in CD-MOF. The molecular simulation demonstrated the configuration of SCU in CD-MOF and its contribution to the free energy of the SCU@CD-MOF, which defined the enhanced laryngeal anchoring. In conclusion, the glycosides-like SCU could effectively enhance the anchoring of CD-MOF particles to the larynx to facilitate the treatment of laryngeal diseases. (C) 2020 Chinese Pharmaceutical Association and Institute of Materia Medica, Chinese Academy of Medical Sciences. Production and hosting by Elsevier B.V. |
| WOS关键词 | METAL-ORGANIC FRAMEWORKS ; DRY-POWDER INHALER ; IN-VITRO ; ENCAPSULATION ; FORMULATION ; STABILITY ; CARRIER ; SYSTEM ; DEPOSITION ; DISORDERS |
| 资助项目 | Strategic Priority Research Program of the Chinese Academy of Sciences (China)[XDA12050307] ; ANR AntiTBnano project (France)[ANR-14-CE08-0017] ; National Research Council of Science and Technology Major Projects for Major New Drugs Innovation and Development (China)[2018ZX09721002e009] |
| WOS研究方向 | Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000577456900010 |
| 出版者 | INST MATERIA MEDICA, CHINESE ACAD MEDICAL SCIENCES |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/291513]  |
| 专题 | 新药研究国家重点实验室 |
| 通讯作者 | Shi, Senlin; Gref, Ruxandra; Zhang, Jiwen |
| 作者单位 | 1.Zhejiang Chinese Med Univ, Coll Pharmaceut Sci, Hangzhou 311402, Peoples R China 2.Chinese Acad Sci, Ctr Drug Delivery Syst, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China 3.Natl Inst Food & Drug Control, NMPA Key Lab Qual Res & Evaluat Pharmaceut Excipi, Beijing 100050, Peoples R China 4.Jiangxi Univ Tradit Chinese Med, Key Lab Modern Chinese Med Preparat, Minist Educ, Nanchang 330004, Jiangxi, Peoples R China 5.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 6.Univ Paris Saclay, Inst Sci Mol Orsay, CNRS 8214, F-91405 Orsay, France |
| 推荐引用方式 GB/T 7714 | Zhao, Kena,Guo, Tao,Wang, Caifen,et al. Glycoside scutellarin enhanced CD-MOF anchoring for laryngeal delivery[J]. ACTA PHARMACEUTICA SINICA B,2020,10(9):1709-1718. |
| APA | Zhao, Kena.,Guo, Tao.,Wang, Caifen.,Zhou, Yong.,Xiong, Ting.,...&Zhang, Jiwen.(2020).Glycoside scutellarin enhanced CD-MOF anchoring for laryngeal delivery.ACTA PHARMACEUTICA SINICA B,10(9),1709-1718. |
| MLA | Zhao, Kena,et al."Glycoside scutellarin enhanced CD-MOF anchoring for laryngeal delivery".ACTA PHARMACEUTICA SINICA B 10.9(2020):1709-1718. |
入库方式： OAI收割
来源：上海药物研究所
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