Diving into the world of marine 2,11-cyclized cembranoids: a summary of new compounds and their biological activities
文献类型：期刊论文
| 作者 | Li, Geng1,2,3; Dickschat, Jeroen S.2; Guo, Yue-Wei1,3
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| 刊名 | NATURAL PRODUCT REPORTS
 |
| 出版日期 | 2020-10-01 |
| 卷号 | 37期号:10页码:1367-1383 |
| ISSN号 | 0265-0568 |
| DOI | 10.1039/d0np00016g |
| 通讯作者 | Dickschat, Jeroen S.(dickschat@uni-bonn.de) ; Guo, Yue-Wei(ywguo@simm.ac.cn) |
| 英文摘要 | Covering: 2010 to 2020 The class of 2,11-cyclized cembranoids is particularly widespread in marine Octocorallia, especially Alcyonacea and Gorgonacea, and has been extensively studied. Following a previous review published in 2010, the accumulated knowledge from the past decade will be presented here. All 2,11-cyclized cembranoids share a bicyclo[8.4.0]tetradecane core that is in most of the known compounds oxidatively modified to result in the 15-oxatricyclo[6.6.1.0(2,7)]pentadecane system. Multiple further oxidation and acylation patterns can be observed, while halogenated compounds are surprisingly rare. One new sulfur-containing and a fewseco-compounds have also been reported. The biosynthetic pathways to this fascinating class of natural products have not been studied to date, but a plausible biosynthetic hypothesis is presented that allows for a structured discussion of the compounds according to their carbon skeletons and oxidation patterns. Biological activities towards 2,11-cyclized diterpenes are also included. |
| WOS关键词 | EUNICELLIN-BASED DITERPENOIDS ; GORGONIAN MURICELLA-SIBOGAE ; ABSOLUTE-CONFIGURATION ; NATURAL-PRODUCTS ; A-H ; SCLEROPHYTIN ; ASBESTININS ; CLADIELLINS ; BRIARELLINS ; TERPENOIDS |
| 资助项目 | Natural Science Foundation of China[81991521] ; Natural Science Foundation of China[81520108028] ; Natural Science Foundation of China[21672230] ; National Key Research and Development Program of China[2018YFC0310903] ; Drug Innovation Major Project[2018ZX09711-001-001-009] ; SKLDR/SIMM Project[SIMM1903ZZ-04] ; CAS-DAAD Joint Scholarship Program |
| WOS研究方向 | Biochemistry & Molecular Biology ; Pharmacology & Pharmacy ; Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000580652200004 |
| 出版者 | ROYAL SOC CHEMISTRY |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/291529]  |
| 专题 | 新药研究国家重点实验室 |
| 通讯作者 | Dickschat, Jeroen S.; Guo, Yue-Wei |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, 555 Zu Chong Zhi Rd,Zhangjiang Hitech Pk, Shanghai 201203, Peoples R China 2.Univ Bonn, Kekule Inst Organ Chem & Biochem, Gerhard Domagk Str 1, D-53121 Bonn, Germany 3.Univ Chinese Acad Sci, 19A Yuquan Rd, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Li, Geng,Dickschat, Jeroen S.,Guo, Yue-Wei. Diving into the world of marine 2,11-cyclized cembranoids: a summary of new compounds and their biological activities[J]. NATURAL PRODUCT REPORTS,2020,37(10):1367-1383. |
| APA | Li, Geng,Dickschat, Jeroen S.,&Guo, Yue-Wei.(2020).Diving into the world of marine 2,11-cyclized cembranoids: a summary of new compounds and their biological activities.NATURAL PRODUCT REPORTS,37(10),1367-1383. |
| MLA | Li, Geng,et al."Diving into the world of marine 2,11-cyclized cembranoids: a summary of new compounds and their biological activities".NATURAL PRODUCT REPORTS 37.10(2020):1367-1383. |
入库方式： OAI收割
来源：上海药物研究所
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