GPR91, a critical signaling mechanism in modulating pathophysiologic processes in chronic illnesses
文献类型：期刊论文
| 作者 | Li, Xinyi1; Xie, Li1; Qu, Xiangli2,6; Zhao, Bangyi3; Fu, Wei3; Wu, Beili2,6 ; Wu, Jian1,4,5
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| 刊名 | FASEB JOURNAL
 |
| 出版日期 | 2020-08-19 |
| 页码 | 15 |
| 关键词 | G protein-coupled receptor innate immunity metabolic regulation succinate SUCNR1 |
| ISSN号 | 0892-6638 |
| DOI | 10.1096/fj.202001037R |
| 通讯作者 | Wu, Beili(beiliwu@simm.ac.cn) ; Wu, Jian(jian.wu@fudan.edu.cn) |
| 英文摘要 | Succinate receptor GPR91 is one of G protein-coupled receptors (GPCRs), and is expressed in a variety of cell types and tissues. Succinate is its natural ligand, and its activation represents that an intrinsic metabolic intermediate exerts a regulatory role on many critical life processes involving pathophysiologic mechanisms, such as innate immunity, inflammation, tissue repair, and oncogenesis. With the illustration of 3-dimensional crystal structure of the receptor and discovery of its antagonists, it is possible to dissect the succinate-GPR91-G protein signaling pathways in different cell types under pathophysiological conditions. Deep understanding of the GPR91-ligand binding mode with various agonists and antagonists would aid in elucidating the molecular basis of a spectrum of chronic illnesses, such as hypertension, diabetes, and their renal and retina complications, metabolic-associated fatty liver diseases, such as nonalcoholic steatohepatitis and its fibrotic progression, inflammatory bowel diseases (Crohn's disease and ulcerative colitis), age-related macular degeneration, rheumatoid arthritis, and progressive behaviors of malignancies. With better delineation of critical regulatory role of the succinate-GPR91 axis in these illnesses, therapeutic intervention may be developed by specifically targeting this signaling pathway with small molecular antagonists or other strategies. |
| WOS关键词 | SUCCINATE RECEPTOR GPR91 ; PROTEIN-COUPLED RECEPTORS ; CELLS ; ACTIVATION ; DISCOVERY ; LEADS ; GPCRS ; DYSFUNCTION ; NANOBODIES ; FUMARATE |
| 资助项目 | National Natural Science Foundation of China[81572356] ; National Natural Science Foundation of China[81871997] ; National Natural Science Foundation of China[31825010] ; National Key R&D Program of China[2016YFE0107400] ; Shanghai Commission of Science and Technology[16140903700] |
| WOS研究方向 | Biochemistry & Molecular Biology ; Life Sciences & Biomedicine - Other Topics ; Cell Biology |
| 语种 | 英语 |
| WOS记录号 | WOS:000567542800001 |
| 出版者 | WILEY |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/291589]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Wu, Beili; Wu, Jian |
| 作者单位 | 1.Fudan Univ, Sch Basic Med Sci, MOE NHC CAMS Key Lab Med Mol Virol, Dept Med Microbiol, Shanghai, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Mat Med, CAS Key Lab Receptor Res, 555 Zhuchongzhi Rd, Shanghai 201203, Peoples R China 3.Fudan Univ, Sch Pharm, Dept Med Chem, Shanghai, Peoples R China 4.Fudan Univ, Zhongshan Hosp, Dept Gastroenterol & Hepatol, Shanghai, Peoples R China 5.Fudan Univ, Shanghai Med Coll, Shanghai Inst Liver Dis, Shanghai, Peoples R China 6.Univ Chinese Acad Sci, Beijing, Peoples R China |
| 推荐引用方式 GB/T 7714 | Li, Xinyi,Xie, Li,Qu, Xiangli,et al. GPR91, a critical signaling mechanism in modulating pathophysiologic processes in chronic illnesses[J]. FASEB JOURNAL,2020:15. |
| APA | Li, Xinyi.,Xie, Li.,Qu, Xiangli.,Zhao, Bangyi.,Fu, Wei.,...&Wu, Jian.(2020).GPR91, a critical signaling mechanism in modulating pathophysiologic processes in chronic illnesses.FASEB JOURNAL,15. |
| MLA | Li, Xinyi,et al."GPR91, a critical signaling mechanism in modulating pathophysiologic processes in chronic illnesses".FASEB JOURNAL (2020):15. |
入库方式： OAI收割
来源：上海药物研究所
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