The homogenous polysaccharide SY01-23 purified from leaf of Morus alba L. has bioactivity on human gut Bacteroides ovatus and Bacteroides cellulosilyticus
文献类型：期刊论文
| 作者 | Wang, Yeqing1,3,4; Shao, Saicong2,3,4; Guo, Ciliang3,4; Zhang, Shihai3,4; Li, Meixia3,4; Ding, Kan3,4
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| 刊名 | INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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| 出版日期 | 2020-09-01 |
| 卷号 | 158页码:698-707 |
| 关键词 | Morus alba L. Polysaccharide Human gut microbiota Cross-feeding Short-chain fatty acids |
| ISSN号 | 0141-8130 |
| DOI | 10.1016/j.ijbiomac.2020.05.009 |
| 通讯作者 | Li, Meixia(limei@simm.ac.cn) ; Ding, Kan(dingkan@simm.ac.cn) |
| 英文摘要 | Function of mulberry leaf (Morus alba L.) polysaccharide has been reported on antitumor, immunostimulatory and anti-inflammatory effects. However, the bioactivity on human gut microbiota is unclear so far. Here, three homogenous polysaccharides named SY01-21, SY01-22, SY01-23 were isolated from mulberry leaf with molec-ular weight 57 kDa, 25 kDa and 7.2 kDa, respectively. The monosaccharide composition of SY01-21 contained rhamnose, galactose and arabinose in a molar ratio of 7.60:43.52:48.88. SY01-22 contained rhamnose, galacturonic acid, glucose, galactose, xylose and arabinose in a molar ratio of 14.61:9.06:1.35:34.65:2.99:37.34. SY01-23 contained rhamnose, glucuronic acid, galacturonic acid, glucose, galactose, xylose and arabinose in a molar ratio of 23.00:4.12:24.60:5.74:17.28:1.12:24.13. Bioactivity test showed SY01-21 promoted the growth of Bacteroides cellulosilyticus (BC) while SY01-22 benefited the growth of Bacteroides ovatus (BO). Interestingly, SY01-23 boosted the growth of both BO and BC. However, Bacteroides thetaiotamicron (BT) only grew on 5 mg/mL SY01-21. Intriguingly, the growth of co-culture of BT with BO or BC was better than monoculture. This suggested that cross-feeding might exist between them. Besides, we found BO and BC generated acetate and propionate by utilizing SY01-23. The above results suggested that SY01-23 might modify human gut micro -biota by driving colonization of Bacteroides in the gut to improve wellness. (C) 2020 Elsevier B.V. All rights reserved. |
| WOS关键词 | CHAIN FATTY-ACIDS ; GC-MS ; EXTRACTION ; THETAIOTAOMICRON ; MICROBIOTA ; THUNB. ; FIBER |
| 资助项目 | Key New Drug Creation and Manufacturing Program[2019ZX09735001] ; Ministry of Science and Technology, the People Republic of China ; National Natural Science Foundation of China[31800673] |
| WOS研究方向 | Biochemistry & Molecular Biology ; Chemistry ; Polymer Science |
| 语种 | 英语 |
| WOS记录号 | WOS:000564489300015 |
| 出版者 | ELSEVIER |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/291598]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Li, Meixia; Ding, Kan |
| 作者单位 | 1.Nanchang Univ, Sch Pharm, Nanchang 330006, Jiangxi, Peoples R China 2.Shanghai Univ Tradit Chinese Med, Tradit Chinese Med Coll, Shanghai 201203, Peoples R China 3.Chinese Acad Sci, Shanghai Inst Mat Med, Glycochem & Glycobiol Lab, Key Lab Receptor Res, 555 Zu Chong Zhi Rd, Shanghai 201203, Peoples R China 4.Univ Chinese Acad Sci, 19A Yuquan Rd, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, Yeqing,Shao, Saicong,Guo, Ciliang,et al. The homogenous polysaccharide SY01-23 purified from leaf of Morus alba L. has bioactivity on human gut Bacteroides ovatus and Bacteroides cellulosilyticus[J]. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,2020,158:698-707. |
| APA | Wang, Yeqing,Shao, Saicong,Guo, Ciliang,Zhang, Shihai,Li, Meixia,&Ding, Kan.(2020).The homogenous polysaccharide SY01-23 purified from leaf of Morus alba L. has bioactivity on human gut Bacteroides ovatus and Bacteroides cellulosilyticus.INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,158,698-707. |
| MLA | Wang, Yeqing,et al."The homogenous polysaccharide SY01-23 purified from leaf of Morus alba L. has bioactivity on human gut Bacteroides ovatus and Bacteroides cellulosilyticus".INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES 158(2020):698-707. |
入库方式： OAI收割
来源：上海药物研究所
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