Anti-hepatitis B virus activity of swertisin isolated from Iris tectorum Maxim
文献类型：期刊论文
| 作者 | Xu, Hong-Yan1; Ren, Ji-Hua1; Su, Yu2,3; Ren, Fang1; Zhou, Yu-Jiao1; Jiang, Hui1; Cheng, Sheng-Tao1; Zhang, Chuan-Rui2,3,4; Chen, Juan1 |
| 刊名 | JOURNAL OF ETHNOPHARMACOLOGY
 |
| 出版日期 | 2020-07-15 |
| 卷号 | 257页码:9 |
| 关键词 | Iris tectorum Maxim Swertisin Hepatitis B virus HBsAg HBeAg |
| ISSN号 | 0378-8741 |
| DOI | 10.1016/j.jep.2020.112787 |
| 通讯作者 | Zhang, Chuan-Rui(crzhang@cqu.edu.cn) ; Chen, Juan(chenjuan2014@cqmu.edu.cn) |
| 英文摘要 | Ethnopharmacological relevance: Iris tectorum Maxim (I. tectorum, Yuan Wei in Chinese) is a common and traditional Chinese medicinal herb that be used to treat liver-related diseases. However, the anti-HBV activity of I. tectorum and its isolates has not been systemically studied. Aim of the study: To screen the active part of I. tectorum and systemically evaluate their anti-HBV activity. Materials and methods: In this study, a series of compounds from I. tectorum were evaluated for their ability to inhibit HBV replication. Swertisin showed a significant inhibitory function on HBV replication. Then, the suppression effect of different concentrations of swertisin in HBsAg, HBeAg and HBV DNA level in HepG2.2.15 cells and HBV-infected HepG2-NTCP cells were comprehensive evaluated, respectively. Moreover, the anti-HBV effects of swertisin were confirmed in HBV transgenic mice model. Results: Among these compounds, swertisin strongly inhibited the HBsAg, HBeAg and HBV DNA level in a dose-dependent manner in HepG2.2.15 cells and HBV-infected HepG2-NTCP cells. Furthermore, swertisin showed a significant inhibition role on HBV replication in HBV transgenic mice model, the inhibition effect of which was enhanced when combined with ETV. Conclusions: We have identified that swertisin can inhibit HBeAg and HBsAg production, as well as HBV DNA in vitro and in vivo. This study show that we may found a novel compound isolated from traditional Chinese medicines with potent anti-HBV function. |
| WOS关键词 | CHINESE HERBAL MEDICINE ; IN-VITRO ; COMBINATION THERAPY ; VIVO ; TECTORIGENIN ; CONSTITUENTS ; REPLICATION ; ISOFLAVONES ; INTERFERON ; FLAVONOIDS |
| 资助项目 | National Natural Science Foundation of China[81861168035] ; National Natural Science Foundation of China[81802015] ; project of science and technology research program of Chongqing Education Commission of China[KJQN201800433] ; State Key Laboratory of Drug Research[SIMM1903KF-14] ; Fundamental Research Funds for the Central Universities in China[106112017CDJQJ468824] |
| WOS研究方向 | Plant Sciences ; Pharmacology & Pharmacy ; Integrative & Complementary Medicine |
| 语种 | 英语 |
| WOS记录号 | WOS:000538156200032 |
| 出版者 | ELSEVIER IRELAND LTD |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/291621]  |
| 专题 | 新药研究国家重点实验室 |
| 通讯作者 | Zhang, Chuan-Rui; Chen, Juan |
| 作者单位 | 1.Chongqing Med Univ, Affiliated Hosp 2, Inst Viral Hepatitis, Dept Infect Dis,Key Lab Mol Biol Infect Dis,Minis, Chongqing, Peoples R China 2.Chongqing Univ, Sch Pharmaceut Sci, Chongqing Key Lab Nat Prod Synth & Drug Res, Chongqing 401331, Peoples R China 3.Chongqing Univ, Sch Pharmaceut Sci, Chem Biol Res Ctr, Chongqing 401331, Peoples R China 4.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai, Peoples R China |
| 推荐引用方式 GB/T 7714 | Xu, Hong-Yan,Ren, Ji-Hua,Su, Yu,et al. Anti-hepatitis B virus activity of swertisin isolated from Iris tectorum Maxim[J]. JOURNAL OF ETHNOPHARMACOLOGY,2020,257:9. |
| APA | Xu, Hong-Yan.,Ren, Ji-Hua.,Su, Yu.,Ren, Fang.,Zhou, Yu-Jiao.,...&Chen, Juan.(2020).Anti-hepatitis B virus activity of swertisin isolated from Iris tectorum Maxim.JOURNAL OF ETHNOPHARMACOLOGY,257,9. |
| MLA | Xu, Hong-Yan,et al."Anti-hepatitis B virus activity of swertisin isolated from Iris tectorum Maxim".JOURNAL OF ETHNOPHARMACOLOGY 257(2020):9. |
入库方式： OAI收割
来源：上海药物研究所
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