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Chemical structure elucidation of an inulin-type fructan isolated from Lobelia chinensis lour with anti-obesity activity on diet-induced mice

文献类型：期刊论文

作者Zhang, Xue1,2; Hu, Pei3; Zhang, Xiaorui4; Li, Xiaojun1,2
刊名CARBOHYDRATE POLYMERS
出版日期2020-07-15
卷号240页码:8
关键词Lobelia chinensis Lour polysaccharides anti-obesity chemical structure inulin-type fructan high fat diet-induced mice
ISSN号0144-8617
DOI10.1016/j.carbpol.2020.116357
通讯作者Hu, Pei(hupeishtcm@126.com) ; Li, Xiaojun(juniors_li@163.com)
英文摘要A neutral polysaccharide (LCPS) was obtained from Lobelia chinensis via hot water extraction and ethanol precipitation. After separation and purification, the homogeneous polysaccharide was obtained with a molecular weight of 2.6x10(3) Da. The chemical composition of the extracted polysaccharide contains fructose and glucose with protein-free identified by gas chromatography-mass spectrometer (GC-MS) method. Chemical structure of LCPS was indicated by nuclear magnetic resonance (NMR) spectroscopy. Data indicated that LCPS was an inulintype fructan with alpha-D-Glcp-(1 ->[1)-beta-D-Fruf-(2](15) linkage. LCPS intake reduced at significant level high fat diet (HFD)-induced body weight gain, liver weight, total cholesterol and triglyceride in serum and hepatic tissue, respectively. The lipid droplet accumulation in hepatic tissue was similar between lean and LCPS groups lower than in HFD-induced mice from tissue section staining results. Together, polysaccharides from Lobelia chinensis could be a new source of natural anti-obesity agent against obesity with potential value in the manufacturing supplements and drugs.
WOS关键词GUT MICROBIOTA ; INDUCED OBESITY ; CALORIE RESTRICTION ; POLYSACCHARIDES ; OLIGOSACCHARIDES ; POLYMERIZATION ; CONSTITUENTS ; INFLAMMATION ; PERFORMANCE ; OVERWEIGHT
WOS研究方向Chemistry ; Polymer Science
语种英语
WOS记录号WOS:000537314900013
出版者ELSEVIER SCI LTD
源URL[http://119.78.100.183/handle/2S10ELR8/291647]  
专题中国科学院上海药物研究所
通讯作者Hu, Pei; Li, Xiaojun
作者单位1.Yangzhou Univ, Inst Translat Med, Med Coll, Yangzhou 225001, Jiangsu, Peoples R China
2.Yangzhou Univ, Jiangsu Key Lab Integrated Tradit Chinese & Weste, Yangzhou 225001, Jiangsu, Peoples R China
3.Chinese Acad Sci, Shanghai Inst Mat Medica, Shanghai, Peoples R China
4.CAS Ctr Excellence Mol Cell Sci, Shanghai, Peoples R China
推荐引用方式
GB/T 7714		 Zhang, Xue,Hu, Pei,Zhang, Xiaorui,et al. Chemical structure elucidation of an inulin-type fructan isolated from Lobelia chinensis lour with anti-obesity activity on diet-induced mice[J]. CARBOHYDRATE POLYMERS,2020,240:8.
APA Zhang, Xue,Hu, Pei,Zhang, Xiaorui,&Li, Xiaojun.(2020).Chemical structure elucidation of an inulin-type fructan isolated from Lobelia chinensis lour with anti-obesity activity on diet-induced mice.CARBOHYDRATE POLYMERS,240,8.
MLA Zhang, Xue,et al."Chemical structure elucidation of an inulin-type fructan isolated from Lobelia chinensis lour with anti-obesity activity on diet-induced mice".CARBOHYDRATE POLYMERS 240(2020):8.

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来源：上海药物研究所

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