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Nanotechnology-Based Histone Deacetylase Inhibitors for Cancer Therapy

文献类型：期刊论文

作者Tu, Bin1,2; Zhang, Meng1; Liu, Tuanbing1; Huang, Yongzhuo1,2,3
刊名FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
出版日期2020-06-03
卷号8页码:8
关键词Histone deacetylase inhibitors (HDACi) nanotechnology nanomedicine cancer therapy solid tumor targeting drug delivery combination therapy
ISSN号2296-634X
DOI10.3389/fcell.2020.00400
通讯作者Zhang, Meng(Zhangmeng3@simm.ac.cn) ; Huang, Yongzhuo(yzhuang@simm.ac.cn)
英文摘要Histone deacetylase inhibitors (HDACi) have been approved and achieved success in hematologic malignancies. But its application in solid tumors still confronts big challenges and is hampered by low treatment efficacy. Nanotechnology has been widely applied in cancer therapy, and nanomedicine could improve drug stability, prolong the circulation half-life, and increase intratumoral drug accumulation. Therefore, nanomedicine is a promising strategy to enhance HDACi therapy efficacy. The review provides a summary of the advances of HDACi nanomedicines with a focus on the design principles of the targeting delivery systems for HDACi.
WOS关键词TUMOR MICROENVIRONMENT ; CO-DELIVERY ; NANOPARTICLES ; COMBINATION ; DRUG ; VORINOSTAT ; CONJUGATE ; NANOINFORMATICS ; DOXORUBICIN ; CELLS
资助项目NFSC[81925035] ; NFSC[81673382] ; NFSC[81521005] ; Strategic Priority Research Program of CAS[XDA12050307] ; National Special Project for Significant Drugs Development[2018ZX09711002-010-002] ; Fudan-SIMM Joint Research Fund[FU-SIMM20174009]
WOS研究方向Cell Biology ; Developmental Biology
语种英语
WOS记录号WOS:000543173700001
出版者FRONTIERS MEDIA SA
源URL[http://119.78.100.183/handle/2S10ELR8/291740]  
专题新药研究国家重点实验室
通讯作者Zhang, Meng; Huang, Yongzhuo
作者单位1.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai, Peoples R China
2.Univ Chinese Acad Sci, Beijing, Peoples R China
3.NMPA Key Lab Qual Res & Evaluat Pharmaceut Excipi, Beijing, Peoples R China
推荐引用方式
GB/T 7714		 Tu, Bin,Zhang, Meng,Liu, Tuanbing,et al. Nanotechnology-Based Histone Deacetylase Inhibitors for Cancer Therapy[J]. FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY,2020,8:8.
APA Tu, Bin,Zhang, Meng,Liu, Tuanbing,&Huang, Yongzhuo.(2020).Nanotechnology-Based Histone Deacetylase Inhibitors for Cancer Therapy.FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY,8,8.
MLA Tu, Bin,et al."Nanotechnology-Based Histone Deacetylase Inhibitors for Cancer Therapy".FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY 8(2020):8.

入库方式： OAI收割

来源：上海药物研究所

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