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Engineering autologous tumor cell vaccine to locally mobilize antitumor immunity in tumor surgical bed

文献类型：期刊论文

作者Fang, Lei1,2,3; Zhao, Zitong1,2,4; Wang, Jue1,2; Zhang, Pengcheng1,2,5; Ding, Yaping3; Jiang, Yanyan4; Wang, Dangge1,2,5; Li, Yaping1,2,5
刊名SCIENCE ADVANCES
出版日期2020-06-01
卷号6期号:25页码:13
ISSN号2375-2548
DOI10.1126/sciadv.aba4024
通讯作者Wang, Dangge(dgwang@simm.ac.cn) ; Li, Yaping(ypli@simm.ac.cn)
英文摘要Autologous tumor cell-based vaccines (ATVs) are emerging as a transformable approach for personalized immunotherapy, but their therapeutic efficacy remains unsatisfying in patients with cancer. Here, we design a photodynamic therapy (PDT)-motivated ATV (P-ATV) in Fmoc-KCRGDK-phenylboronic acid (FK-PBA) hydrogel, which mobilizes local immune activation to inhibit relapse of postoperative tumors. The FK-PBA targeting overexpressed sialic acid on tumor cells can enable on-demand gelation in residue tumor areas and maintain continuous vaccination in surgical bed. Unlike neoantigen-based vaccine or adoptive cell therapy that takes several months to prepare, P-ATV can be easily manufactured within a few days and efficiently boost neoepitope-specific CD8(+) T cells to activate personalized immunotherapy. This simple and powerful approach of engineered ATVs provides an alternative strategy for personalized immunotherapy and is readily transformable to various kinds of cell-based antigens to inhibit the relapse of postoperative tumors.
WOS关键词CANCER-IMMUNOTHERAPY ; HYPOCHLOROUS ACID ; LYSATE ; MICELLES ; ADJUVANT ; THERAPY
资助项目National Natural Science Foundation of China[81690265] ; National Natural Science Foundation of China[81803444] ; National Natural Science Foundation of China[81521005] ; National Natural Science Foundation of China[81903548] ; Strategic Priority Research Program of CAS[XDA12050307] ; Youth Innovation Promotion Association of CAS[2019283] ; Shanghai Sailing Program[19YF1457300]
WOS研究方向Science & Technology - Other Topics
语种英语
WOS记录号WOS:000542299800020
出版者AMER ASSOC ADVANCEMENT SCIENCE
源URL[http://119.78.100.183/handle/2S10ELR8/291746]  
专题新药研究国家重点实验室
通讯作者Wang, Dangge; Li, Yaping
作者单位1.Chinese Acad Sci, State Key Lab Drug Res, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China
2.Chinese Acad Sci, Ctr Pharmaceut, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China
3.Shanghai Univ, Coll Sci, Shanghai 200444, Peoples R China
4.Fudan Univ, Sch Pharm, Shanghai 201203, Peoples R China
5.Yantai Inst Mat Med, Yantai Key Lab Nanomed & Adv Preparat, Yantai 264000, Shandong, Peoples R China
推荐引用方式
GB/T 7714		 Fang, Lei,Zhao, Zitong,Wang, Jue,et al. Engineering autologous tumor cell vaccine to locally mobilize antitumor immunity in tumor surgical bed[J]. SCIENCE ADVANCES,2020,6(25):13.
APA Fang, Lei.,Zhao, Zitong.,Wang, Jue.,Zhang, Pengcheng.,Ding, Yaping.,...&Li, Yaping.(2020).Engineering autologous tumor cell vaccine to locally mobilize antitumor immunity in tumor surgical bed.SCIENCE ADVANCES,6(25),13.
MLA Fang, Lei,et al."Engineering autologous tumor cell vaccine to locally mobilize antitumor immunity in tumor surgical bed".SCIENCE ADVANCES 6.25(2020):13.

入库方式： OAI收割

来源：上海药物研究所

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