中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
Targeted isolation of two disesquiterpenoid macrocephadiolides A and B fromAinsliaea macrocephalausing a molecular networking-based dereplication strategy

文献类型:期刊论文

作者Ren, Yong-Mei1,2,3,4; Zhou, Shuai-Zhen1,2; Zhang, Tian5; Qian, Meijia6; Zhang, Rui1,2; Yao, Sheng1,2; Zhu, Hong6; Tang, Chunping1,2; Lin, Ligen5; Ye, Yang1,2,3,4
刊名ORGANIC CHEMISTRY FRONTIERS
出版日期2020-06-21
卷号7期号:12页码:1481-1489
ISSN号2052-4129
DOI10.1039/d0qo00030b
通讯作者Lin, Ligen() ; Ye, Yang(yye@simm.ac.cn)
英文摘要A molecular networking-based dereplication strategy was applied for the phytochemical investigation ofAinsliaea macrocephala, leading to the isolation of two novel disesquiterpenoid macrocephadiolides A (1) and B (2). Their structures, featuring a rare 5,6-spirocyclic ketal lactone core and a C-15/C-15 ' linkage between a guaianolide and a 3,4-seco-guaianolide monomer, respectively, were established by extensive spectroscopic analysis and confirmed further by single-crystal X-ray crystallography. Compounds1and2showed a potent inhibitory effect on nitric oxide (NO) production, with IC(50)values of 0.99 and 6.13 mu M, respectively, in lipopolysaccharide (LPS)-stimulated RAW264.7 macrophages. Compound1dose-dependently suppressed the expression of inducible NO oxidase (iNOS) through inhibiting nuclear factor-kappa B (NF-kappa B) activation.
WOS关键词NATURAL-PRODUCTS ; SESQUITERPENE LACTONES ; BIOMIMETIC SYNTHESES ; CONSTITUENTS ; RENAISSANCE
资助项目National Natural Science Foundation of China[81673327] ; National Natural Science Foundation of China[81903485] ; National Natural Science Foundation of China[81872754] ; China National Key RD Program[2017YFE0195100] ; China National Key RD Program[2018YFC1707000] ; National Key R&D Program of China[2017YFE0102200]
WOS研究方向Chemistry
语种英语
出版者ROYAL SOC CHEMISTRY
WOS记录号WOS:000542743600007
源URL[http://119.78.100.183/handle/2S10ELR8/291772]  
专题新药研究国家重点实验室
通讯作者Lin, Ligen; Ye, Yang
作者单位1.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China
2.Chinese Acad Sci, Shanghai Inst Mat Med, Nat Prod Chem Dept, Shanghai 201203, Peoples R China
3.ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai 201210, Peoples R China
4.Univ Chinese Acad Sci, 19A Yuquan Rd, Beijing 100049, Peoples R China
5.Univ Macau, Inst Chinese Med Sci, State Key Lab Qual Res Chinese Med, Taipa, Macao, Peoples R China
6.Zhejiang Univ, Coll Pharmaceut Sci, Inst Pharmacol & Toxicol, Hangzhou 310058, Peoples R China
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GB/T 7714
Ren, Yong-Mei,Zhou, Shuai-Zhen,Zhang, Tian,et al. Targeted isolation of two disesquiterpenoid macrocephadiolides A and B fromAinsliaea macrocephalausing a molecular networking-based dereplication strategy[J]. ORGANIC CHEMISTRY FRONTIERS,2020,7(12):1481-1489.
APA Ren, Yong-Mei.,Zhou, Shuai-Zhen.,Zhang, Tian.,Qian, Meijia.,Zhang, Rui.,...&Ye, Yang.(2020).Targeted isolation of two disesquiterpenoid macrocephadiolides A and B fromAinsliaea macrocephalausing a molecular networking-based dereplication strategy.ORGANIC CHEMISTRY FRONTIERS,7(12),1481-1489.
MLA Ren, Yong-Mei,et al."Targeted isolation of two disesquiterpenoid macrocephadiolides A and B fromAinsliaea macrocephalausing a molecular networking-based dereplication strategy".ORGANIC CHEMISTRY FRONTIERS 7.12(2020):1481-1489.

入库方式: OAI收割

来源:上海药物研究所

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