Targeted isolation of two disesquiterpenoid macrocephadiolides A and B fromAinsliaea macrocephalausing a molecular networking-based dereplication strategy
文献类型:期刊论文
作者 | Ren, Yong-Mei1,2,3,4; Zhou, Shuai-Zhen1,2; Zhang, Tian5; Qian, Meijia6; Zhang, Rui1,2; Yao, Sheng1,2; Zhu, Hong6; Tang, Chunping1,2; Lin, Ligen5; Ye, Yang1,2,3,4 |
刊名 | ORGANIC CHEMISTRY FRONTIERS |
出版日期 | 2020-06-21 |
卷号 | 7期号:12页码:1481-1489 |
ISSN号 | 2052-4129 |
DOI | 10.1039/d0qo00030b |
通讯作者 | Lin, Ligen() ; Ye, Yang(yye@simm.ac.cn) |
英文摘要 | A molecular networking-based dereplication strategy was applied for the phytochemical investigation ofAinsliaea macrocephala, leading to the isolation of two novel disesquiterpenoid macrocephadiolides A (1) and B (2). Their structures, featuring a rare 5,6-spirocyclic ketal lactone core and a C-15/C-15 ' linkage between a guaianolide and a 3,4-seco-guaianolide monomer, respectively, were established by extensive spectroscopic analysis and confirmed further by single-crystal X-ray crystallography. Compounds1and2showed a potent inhibitory effect on nitric oxide (NO) production, with IC(50)values of 0.99 and 6.13 mu M, respectively, in lipopolysaccharide (LPS)-stimulated RAW264.7 macrophages. Compound1dose-dependently suppressed the expression of inducible NO oxidase (iNOS) through inhibiting nuclear factor-kappa B (NF-kappa B) activation. |
WOS关键词 | NATURAL-PRODUCTS ; SESQUITERPENE LACTONES ; BIOMIMETIC SYNTHESES ; CONSTITUENTS ; RENAISSANCE |
资助项目 | National Natural Science Foundation of China[81673327] ; National Natural Science Foundation of China[81903485] ; National Natural Science Foundation of China[81872754] ; China National Key RD Program[2017YFE0195100] ; China National Key RD Program[2018YFC1707000] ; National Key R&D Program of China[2017YFE0102200] |
WOS研究方向 | Chemistry |
语种 | 英语 |
出版者 | ROYAL SOC CHEMISTRY |
WOS记录号 | WOS:000542743600007 |
源URL | [http://119.78.100.183/handle/2S10ELR8/291772] |
专题 | 新药研究国家重点实验室 |
通讯作者 | Lin, Ligen; Ye, Yang |
作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Mat Med, Nat Prod Chem Dept, Shanghai 201203, Peoples R China 3.ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai 201210, Peoples R China 4.Univ Chinese Acad Sci, 19A Yuquan Rd, Beijing 100049, Peoples R China 5.Univ Macau, Inst Chinese Med Sci, State Key Lab Qual Res Chinese Med, Taipa, Macao, Peoples R China 6.Zhejiang Univ, Coll Pharmaceut Sci, Inst Pharmacol & Toxicol, Hangzhou 310058, Peoples R China |
推荐引用方式 GB/T 7714 | Ren, Yong-Mei,Zhou, Shuai-Zhen,Zhang, Tian,et al. Targeted isolation of two disesquiterpenoid macrocephadiolides A and B fromAinsliaea macrocephalausing a molecular networking-based dereplication strategy[J]. ORGANIC CHEMISTRY FRONTIERS,2020,7(12):1481-1489. |
APA | Ren, Yong-Mei.,Zhou, Shuai-Zhen.,Zhang, Tian.,Qian, Meijia.,Zhang, Rui.,...&Ye, Yang.(2020).Targeted isolation of two disesquiterpenoid macrocephadiolides A and B fromAinsliaea macrocephalausing a molecular networking-based dereplication strategy.ORGANIC CHEMISTRY FRONTIERS,7(12),1481-1489. |
MLA | Ren, Yong-Mei,et al."Targeted isolation of two disesquiterpenoid macrocephadiolides A and B fromAinsliaea macrocephalausing a molecular networking-based dereplication strategy".ORGANIC CHEMISTRY FRONTIERS 7.12(2020):1481-1489. |
入库方式: OAI收割
来源:上海药物研究所
浏览0
下载0
收藏0
其他版本
除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。