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Long non-coding RNAs in hepatocellular carcinoma: Ordering of the complicated lncRNA regulatory network and novel strategies for HCC clinical diagnosis and treatment

文献类型：期刊论文

作者Li, Changyao1,2; Yang, Junfa1,3,4; Liu, Chongjing2; Wang, Xiao5; Zhang, Lei1,3,4
刊名PHARMACOLOGICAL RESEARCH
出版日期2020-08-01
卷号158页码:11
关键词Hepatocellular carcinoma Long non-coding RNA Exosomes
ISSN号1043-6618
DOI10.1016/j.phrs.2020.104848
通讯作者Wang, Xiao(wangxiao@ahmu.edu.cn) ; Zhang, Lei(zhanglei-1@ahmu.edu.cn)
英文摘要Although hepatocellular carcinoma (HCC) is a type of carcinoma with high malignancy, high morbidity and low survival rate, its underlying mechanism has not been entirely elucidated. Abnormal lncRNAs involve many diseases such as neurological diseases, tumors, cardiovascular diseases, immune-mediated disorders, and genetic disorders. The abnormal expression of several lncRNAs is involved in HCC. This paper describes the roles of lncRNAs in promoting and maintaining tumor initiation and progression, interactions between lncRNAs and miRNAs, and exosomes associated with lncRNAs in HCC. We introduce their prospective clinical applications as tumor markers for the diagnosis, treatment, prognosis, and recurrence of HCC. This paper will help us better understand how lncRNAs produce their effects on HCC and provide general directions and strategies to conduct further research.
WOS关键词CANCER STEM-CELLS ; EPITHELIAL-MESENCHYMAL TRANSITION ; ENDOPLASMIC-RETICULUM STRESS ; NF-KAPPA-B ; MOLECULAR-MECHANISMS ; DOWN-REGULATION ; POOR-PROGNOSIS ; EXPRESSION ; PROLIFERATION ; INVASION
资助项目Intercollegiate Key Projects of Nature Science of Anhui Province[KJ2014A124] ; Intercollegiate Key Projects of Nature Science of Anhui Province[KJ2017A169] ; Anhui Natural Science Foundation[1608085MH234] ; Key Research Foundation of Higher Education of Anhui Province[gxfx2017011]
WOS研究方向Pharmacology & Pharmacy
语种英语
WOS记录号WOS:000542124500038
出版者ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
源URL[http://119.78.100.183/handle/2S10ELR8/291787]  
专题中国科学院上海药物研究所
通讯作者Wang, Xiao; Zhang, Lei
作者单位1.Anhui Med Univ, Sch Pharm, 81 Meishan Rd, Hefei 230032, Peoples R China
2.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 200000, Peoples R China
3.Anhui Inst Innovat Drugs, Anhui Prov Lab Inflammatory & Immune Dis, Hefei 230032, Peoples R China
4.Anhui Med Univ, Minist Educ, Key Lab Antiinflammatory & Immune Med, Hefei 230032, Peoples R China
5.Anhui Med Univ, Affiliated Hosp 1, Dept Radiol, 218 Ji Xi Rd, Hefei 230022, Peoples R China
推荐引用方式
GB/T 7714		 Li, Changyao,Yang, Junfa,Liu, Chongjing,et al. Long non-coding RNAs in hepatocellular carcinoma: Ordering of the complicated lncRNA regulatory network and novel strategies for HCC clinical diagnosis and treatment[J]. PHARMACOLOGICAL RESEARCH,2020,158:11.
APA Li, Changyao,Yang, Junfa,Liu, Chongjing,Wang, Xiao,&Zhang, Lei.(2020).Long non-coding RNAs in hepatocellular carcinoma: Ordering of the complicated lncRNA regulatory network and novel strategies for HCC clinical diagnosis and treatment.PHARMACOLOGICAL RESEARCH,158,11.
MLA Li, Changyao,et al."Long non-coding RNAs in hepatocellular carcinoma: Ordering of the complicated lncRNA regulatory network and novel strategies for HCC clinical diagnosis and treatment".PHARMACOLOGICAL RESEARCH 158(2020):11.

入库方式： OAI收割

来源：上海药物研究所

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