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Engineering Polymeric Prodrug Nanoplatform for Vaccination Immunotherapy of Cancer

文献类型：期刊论文

作者Zhou, Lei1,2,4; Hou, Bo1,2; Wang, Dangge1,2; Sun, Fang1,2; Song, Rundi1,2; Shao, Qian5; Wang, Hao4; Yu, Haijun1,2,3; Li, Yaping1,2,3
刊名NANO LETTERS
出版日期2020-06-10
卷号20期号:6页码:4393-4402
关键词Polymeric prodrug Neoantigen Adaptive immune response Personalized immunotherapy Nanoparticles
ISSN号1530-6984
DOI10.1021/acs.nanolett.0c01140
通讯作者Yu, Haijun(hjyu@simm.ac.cn) ; Li, Yaping(ypli@simm.ac.cn)
英文摘要Neoantigen-based cancer vaccines are promising for boosting cytotoxic T lymphocyte (CTL) responses. However, the therapeutic effect of cancer vaccines is severely blunted by functional suppression of the dendritic cells (DCs). Herein, we demonstrated an acid-responsive polymeric nanovaccine for activating the stimulator of interferon genes (STING) pathway and improving cancer immunotherapy. The nanovaccines were fabricated by integrating an acid-activatable polymeric conjugate of the STING agonist and neoantigen into one single nanoplatform. The nanovaccines efficiently accumulated at the lymph nodes for promoting DC uptake and facilitating cytosol release of the neoantigens. Meanwhile, the STING agonist activated the STING pathway in the DCs to elicit interferon-beta secretion and to boost T-cell priming with the neoantigen. The nanovaccine dramatically inhibited tumor growth and occurrence of B16-OVA melanoma and 4T1 breast tumors in immunocompetent mouse models. Combination immunotherapy with the nanovaccines and anti-PD-L1 antibody demonstrated further improved antitumor efficacy in a 4T1 breast tumor model.
WOS关键词INNATE IMMUNE RECOGNITION ; DENDRITIC CELLS ; POTENT ; DELIVERY ; MICROENVIRONMENT ; NANOPARTICLES ; MICELLEPLEXES ; INTERFERONS ; NANOVACCINE ; ACTIVATION
资助项目National Natural Science Foundation of China[51873228] ; National Natural Science Foundation of China[31671024] ; National Natural Science Foundation of China[81521005] ; Natural Science Foundation of Shandong Province[ZR2019LZL020] ; State Key Laboratory of Drug Research[SIMM2004KF-04]
WOS研究方向Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
语种英语
WOS记录号WOS:000541691200043
出版者AMER CHEMICAL SOC
源URL[http://119.78.100.183/handle/2S10ELR8/291801]  
专题新药研究国家重点实验室
通讯作者Yu, Haijun; Li, Yaping
作者单位1.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China
2.Chinese Acad Sci, Shanghai Inst Mat Med, Ctr Pharmaceut, Shanghai 201203, Peoples R China
3.Yantai Inst Mat Med, Yantai Key Lab Nanomedicole & Adv Preparat, Yantai 264000, Shandong, Peoples R China
4.China State Inst Pharmaceut Ind, Shanghai 201203, Peoples R China
5.Shandong Inst Canc Prevent & Treatment, Jinan 250117, Shandong, Peoples R China
推荐引用方式
GB/T 7714		 Zhou, Lei,Hou, Bo,Wang, Dangge,et al. Engineering Polymeric Prodrug Nanoplatform for Vaccination Immunotherapy of Cancer[J]. NANO LETTERS,2020,20(6):4393-4402.
APA Zhou, Lei.,Hou, Bo.,Wang, Dangge.,Sun, Fang.,Song, Rundi.,...&Li, Yaping.(2020).Engineering Polymeric Prodrug Nanoplatform for Vaccination Immunotherapy of Cancer.NANO LETTERS,20(6),4393-4402.
MLA Zhou, Lei,et al."Engineering Polymeric Prodrug Nanoplatform for Vaccination Immunotherapy of Cancer".NANO LETTERS 20.6(2020):4393-4402.

入库方式： OAI收割

来源：上海药物研究所

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